Heterosynaptic long-term depression of craniofacial nociception: divergent effects on pain perception and blink reflex in man.

Noxious low-frequency stimulation (LFS) of presynaptic nerve fibers induces long-term depression (LTD) of synaptic transmission. In vitro studies suggest a sole homosynaptic effect. Consequently, the present study addressed the hypothesis that LTD of craniofacial nociception in man is mediated by a homosynaptic mechanism.

Peripheral nerve stimulation inhibits nociceptive processing: an electrophysiological study in healthy volunteers.

Objectives.  Electric peripheral nerve stimulation (PNS) is a neuromodulatory therapy in pain patients. The efficacy of this neurosurgical pain treatment is controversial because its antinociceptive effect in humans has not been objectively proven so far.