Growing up with Down syndrome: Development from 6 months to 10.7 years.

Background: We analysed developmental outcomes from a clinical trial early in life and its follow-up at 10.7 years in 123 children with Down syndrome.

Aims: To determine 1) strengths and weaknesses in adaptive functioning and motor skills at 10.

The effect of thyroxine treatment started in the neonatal period on development and growth of two-year-old Down syndrome children: a randomized clinical trial.

Context: Young Down syndrome children appear to have a mild form of congenital hypothyroidism that is rarely detected by neonatal screening and usually left untreated.

Objective: To investigate the effects of thyroxine treatment on development and growth of young Down syndrome children.

Design, Setting, And Participants: Single-center, randomized, double-blind, 24-month trial (enrollment June 1999 to August 2001) with nationwide recruitment, comparing thyroxine administration with placebo in 196 Down syndrome neonates.