Publications by authors named "Susanne Heydt"
Objectives: To evaluate the safety and clinical outcome of bleomycin electrosclerotherapy (BEST) for treating extracranial slow-flow malformations.
Methods: In this retrospective investigation of a multicenter cohort presenting symptomatic slow-flow malformations, patient records were analyzed with respect to procedural details and complications. A treatment-specific, patient-reported questionnaire was additionally evaluated, obtained 3-12 months after the last treatment, to assess the subjective outcomes, including mobility, aesthetic aspects, and pain, as well as the occurrence of postprocedural skin hyperpigmentation.
Background/objective: Oral malformations of the tongue are exceedingly rare. The aim of this study was to evaluate the effectiveness of individualized treatment for patients with vascular malformations of the tongue.
Methods: This retrospective study is based on a consecutive local registry at a tertiary care Interdisciplinary Center for Vascular Anomalies.
Article Synopsis
- Sleep problems in infants treated with propranolol for hemangiomas may indicate potential central nervous system effects; however, this study objectively compares the sleep behavior of treated infants with healthy controls.
- The study involved 54 infants in both groups monitored for sleep using actigraphy and diaries over 7-10 days at 3 and 6 months; findings at 6 months showed treated infants had decreased sleep efficiency and more nighttime awakenings.
- Despite these changes, 24-hour total sleep remained stable, and no negative impact on subjective sleep quality or behavioral development was observed, supporting the use of propranolol as a first-line treatment for infantile hemangiomas.
Bleomycin electrosclerotherapy in therapy-resistant venous malformations of the body.
J Vasc Surg Venous Lymphat Disord
May 2021
Article Synopsis
- The study aimed to evaluate the effectiveness of combining reversible electroporation with bleomycin in treating patients with slow-flow vascular malformations that had not responded to prior treatments.
- A total of 17 patients, averaging 20.8 years old, underwent this new combined treatment method, displaying significant reductions in lesion size — an average decrease from 24.9 cm to 3.5 cm.
- Results indicated that after a few months, half of the patients were symptom-free, suggesting that bleomycin electrosclerotherapy could be promising for those with resistant venous malformations, though larger studies are needed for more definitive conclusions.
In recent years, our knowledge of congenital melanocytic nevi (CMN) has greatly expanded. This has led to a paradigm shift. The present article represents a commentary by an interdisciplinary group of physicians from German-speaking countries with extensive experience in long-term care and surgical treatment of children and adults with CMN (CMN surgery network, "Netzwerk Nävuschirurgie", NNC).
View Article and Find Full Text PDFAgeing is the predominant risk factor for cardiovascular diseases and contributes to a significantly worse outcome in patients with acute myocardial infarction. MicroRNAs (miRNAs) have emerged as crucial regulators of cardiovascular function and some miRNAs have key roles in ageing. We propose that altered expression of miRNAs in the heart during ageing contributes to the age-dependent decline in cardiac function.
View Article and Find Full Text PDFThe shear-responsive transcription factor Krüppel-like factor 2 (KLF2) is a critical regulator of endothelial gene expression patterns induced by atheroprotective flow. As microRNAs (miRNAs) post-transcriptionally control gene expression in many pathogenic and physiological processes, we investigated the regulation of miRNAs by KLF2 in endothelial cells. KLF2 binds to the promoter and induces a significant upregulation of the miR-143/145 cluster.
View Article and Find Full Text PDFRationale: Aging represents a major risk factor for coronary artery disease and aortic aneurysm formation. MicroRNAs (miRs) have emerged as key regulators of biological processes, but their role in age-associated vascular pathologies is unknown.
Objective: We aim to identify miRs in the vasculature that are regulated by age and play a role in age-induced vascular pathologies.