Publications by authors named "Susanne Hagedorn"
Article Synopsis
- Cytomegalovirus (CMV) infections are common in patients getting haematopoietic cell transplantation (HCT) and can lead to serious health issues. Letermovir is a prophylactic treatment that's effective for adults but not yet approved for kids.
- A study was done on 17 pediatric HCT patients to see how letermovir worked for preventing or treating CMV infection since they received it outside of clinical trials.
- Results showed that letermovir helped manage CMV effectively; most patients either had no viral replication or only temporary viral activity, and there were no significant side effects leading to treatment discontinuation.
Androgen deprivation therapy (ADT) is the main therapeutic option for advanced prostate cancer (PCa). After initial regression, most tumors develop into castration-resistant PCa (CRPC). Previously, we found the Mediator complex subunit MED15 to be overexpressed in CRPC and to correlate with clinical outcome.
View Article and Find Full Text PDFProstate cancer is mostly diagnosed at an early stage; however, some tumors are diagnosed in a metastatic stage as cancer of unknown primary origin. In order to allow specific treatment in the case of prostate cancer presenting as cancer of unknown primary origin, it is important to determine the tumor origin. Prostate-specific antigen is used as a diagnostic marker for prostate cancer but the expression declines with progression to castration-resistant prostate cancer.
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