Combined endoscopic and laparoscopic surgery (CELS) for early colon cancer in high-risk patients.

Background: Local excision of early colon cancers could be an option in selected patients with high risk of complications and no sign of lymph node metastasis (LNM). The primary aim was to assess feasibility in high-risk patients with early colon cancer treated with Combined Endoscopic and Laparoscopic Surgery (CELS).

Methods: A non-randomized prospective feasibility study including 25 patients with Performance Status score ≥ 1 and/or American Society of Anesthesiologists score ≥ 3, and clinical Union of International Cancer Control stage-1 colon cancer suitable for CELS resection.

The topographical distribution of lymph node metastases in colon cancer resections.

In accordance with international guidelines all lymph nodes in colon cancer specimens must be examined to obtain accurate staging. This study aimed to determine the topographical location of lymph node metastases and evaluate if a more limited sampling approach could be an alternative. Partial colectomies received at the Department of Pathology, Zealand University Hospital during a six-month period were included.

[Not Available].

Cancer is a cause of high morbidity and mortality. It is not uncommon for a patient to have more than one primary tumour. This review summarises the knowledge of collision tumours which are defined as two adjacent neoplasms in the same organ, while a collision metastasis is the rare occurrence of two different primary cancers metastasising to the same anatomical site.

Perioperative changes in cell-free DNA for patients undergoing surgery for colon cancer.

Background: Various conditions with cellular decay are associated with elevated cell-free DNA (cfDNA). This study aimed to investigate if perioperatively measured cfDNA levels were associated with the surgical approach, complications, or recurrence.

Methods: Plasma was obtained from patients who underwent surgery for colon cancer at admission and at the time of discharge.

Deeper sections reveal residual tumor cells in rectal cancer specimens diagnosed with pathological complete response following neoadjuvant treatment.

Guidelines and requirements for diagnosing pathological complete response (pCR) in rectal adenocarcinoma following neoadjuvant treatment vary, and there is currently no consensus on the appropriate number of sections to examine per formalin-fixed, paraffin-embedded (FFPE) tissue block. The consequences of systematic use of deeper sections on the diagnostic accuracy and prognosis for patients classified as ypT0 rectal cancer were investigated. In this retrospective study, 23 out of 155 patients who underwent neoadjuvant therapy and surgical resection between 2015 and 2020 were diagnosed with ypT0 rectal cancer.

An exploration of immunohistochemistry-based prognostic markers in patients undergoing curative resections for colon cancer.

Background: The immune system recognizes and destroys cancer cells. However, cancer cells develop mechanisms to avoid detection by expressing cell surface proteins. Specific tumour cell surface proteins (e.

Deep learning identifies inflamed fat as a risk factor for lymph node metastasis in early colorectal cancer.

The spread of early-stage (T1 and T2) adenocarcinomas to locoregional lymph nodes is a key event in disease progression of colorectal cancer (CRC). The cellular mechanisms behind this event are not completely understood and existing predictive biomarkers are imperfect. Here, we used an end-to-end deep learning algorithm to identify risk factors for lymph node metastasis (LNM) status in digitized histopathology slides of the primary CRC and its surrounding tissue.

In vivo and ex vivo sentinel node mapping does not identify the same lymph nodes in colon cancer.

Introduction: Identification of lymph nodes and pathological analysis is crucial for the correct staging of colon cancer. Lymph nodes that drain directly from the tumor area are called "sentinel nodes" and are believed to be the first place for metastasis. The purpose of this study was to perform sentinel node mapping in vivo with indocyanine green and ex vivo with methylene blue in order to evaluate if the sentinel lymph nodes can be identified by both techniques.

Impact of in Vivo Ischemic Time on RNA Quality--Experiences from a Colon Cancer Biobank.

Considerable effort has been made to improve differentiated diagnostics as well as personalized treatment for colorectal cancer patients. High-quality fresh frozen tissue is often required to investigate relevant molecular signatures in these patients. In RNA expression studies, the "RNA integrity number" is widely accepted as a reliable marker of RNA quality.

High interleukin-6 mRNA expression is a predictor of relapse in colon cancer.

Aim: To investigate the expression of interleukin-6 (IL6) in colon cancer tissue, and to examine if the risk of relapse is influenced by IL6 expression.

Materials And Methods: Fresh-frozen biopsies from tumor and normal adjacent tissues were taken from patients with colon cancer during surgery and stored at -80 °C. mRNA expression for interleukin-6 was evaluated with reverse transcription real time quantitative polymerase chain reaction.

[The first case of cap polyposis in Denmark].

Cap polyposis (CP) is characterized by the presence of inflammatory polyps mainly involving the rectosigmoid. It primarily causes mucous to bloody diarrhoea and is often misdiagnosed initially. We report the first case in Denmark with multiple polyps in the rectosigmoid causing constipation in between periods of mucous and bloody diarrhoea.

[Caecal diverticulitis in a young woman with suspected acute appendicitis].

Colonic diverticular disease is common amongst the western population in the left hemicolon while right-sided involvement is rare. This case concerns a 20-year-old female, who was hospitalized with suspected acute appendicitis. Perioperative findings included an intramural tumour at the base of the appendix, and an ileocaecal resection was performed.

[Not all dietary supplements are biodegradable].

A 65-year-old man had for some time noticed rounded elements in his faeces. It was examined for parasites, which were, however, not detected. A specimen was then sent to a department of pathology.

Endoscopic brush cytology from the biliary duct system is still valuable.

Introduction: The aim of this study was to define sensitivity, specificity and positive and negative predictive values of endoscopic retrograde cholangiopancreatography (ERCP) brush cytology from biliary strictures obtained over a period of 12 years in a county hospital in Denmark.

Material And Methods: Patients with cytology specimens identified by brushings of the bile duct, pancreatic duct and ampulla of Vater were included. The specimens were reported as unsatisfactory, normal, atypical, suspicious for malignancy or malignant.

[Pilonidal disease is a benign condition].

Malignant transformation in pilonidal disease is rare and never reported in Denmark. There are 75 cases in the literature, mostly squamous cell carcinoma. The cost-benefit of routine histological examination of specimens from pilonidal surgery is questionable, as malignancy is extremely rare.

Total mesocolic excision versus traditional resection in right-sided colon cancer - method and increased lymph node harvest.

Introduction: Rectal surgery has followed a steady trend towards improved surgical techniques over the past 15 years. Danish colon cancer surgery has not witnessed similar progress. Hohenberger described a comprehensive method involving complete excision of all mesocolic tissue which is equivalent to right-sided hemicolectomy.

[Epithelioid trophoblastic tumour].

Epithelioid trophoblastic tumour is a rare gestational trophoblastic disease. The diagnosis is based on microscopic morphology and immunohistochemical staining. It is important to avoid misdiagnosis, as this tumour is primarily treated by surgery rather than chemotherapy.

[Intestinal tuberculosis as a differential diagnosis of inflammatory bowel disease].

Intestinal tuberculosis (ITB) is a rare differential diagnosis of inflammatory bowel disease (IBD) in Denmark. In the presented case, a 44-year-old native Danish man was examined for IBD symptoms. Colonoscopy and microscopy of colonic biopsies suggested IBD.

[Sarcomatoid mesothelioma--a diagnostic challenge].

This is the case of a 62-year-old carpenter in whom a computed tomography showed a widespread "mesothelioma-like" tumour of the pleura. Needle biopsy and later autopsy showed malignant sarcomatoid tumour. The tumour stained negatively for calretinin and other "mesothelial markers".

[Rhabdomyoma in the head and neck region].

Extracardiac rhabdomyoma is an extremely uncommon benign neoplasm with skeletal muscle differentiation which usually involves the head and neck region. We report two cases of extracardiac adult rhabdomyoma affecting adult patients and initially seen as slowly-growing, indolent neoplasms. In both cases, an asymptomatic neck mass was noticed by the patient.

[Multiple synchronous tumours of different histological type of the salivary glands].

Multiple tumours of different histological type of the salivary glands are extremely rare. Here we report a 72-year-old woman who was diagnosed with simultaneously occurring Warthin's tumour of the left parotid and mixed tumour of the homolateral submandibular gland. To our knowledge this combination of histology and localization has not been reported previously.