Publications by authors named "Susanne Billmann"
Alterations in splicing patterns of genes contribute to the regulation of gene function by generating endogenous inhibitor or activator molecules. Nucleotide-binding and oligomerization domain (NOD) 2 is an intracellular receptor for bacterial cell wall components and plays an important role in initiating immune responses against cytoinvasive pathogens. NOD2 overexpression sensitizes intestinal epithelial cells toward bacterial cell wall components, activates the proinflammatory transcription factor NF-kappaB, and induces the subsequent release of the chemotactic cytokine IL-8.
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- NOD2 is a receptor that recognizes bacterial components and is linked to an increased risk of Crohn disease due to genetic variants.
- The study analyzed protein expression changes in human cells with normal (NOD2(WT)) and disease-associated (NOD2(SNP13)) variants after stimulation with muramyl dipeptide (MDP).
- Results showed distinct protein responses, highlighting a pro-inflammatory program regulated by NOD2(WT) and suggesting potential proteomic markers for understanding chronic inflammatory bowel disease.