Publications by authors named "Susanne Bethell"
Article Synopsis
- Researchers identified and characterized two new inhibitors specifically targeting the fibroblast growth factor receptor (FGFR) family, which are important for cell signaling in various cancers.
- These inhibitors show a strong preference for FGFR over a similar receptor, VEGFR2, when tested in lab cell lines and living organisms.
- The effectiveness of these inhibitors was evaluated across different human tumor cell lines with known genetic changes that activate FGFR, suggesting their potential clinical use in treating FGFR-related diseases.
Using a pyrrolidine-5,5-trans-lactam template, we have designed small, neutral, mechanism-based inhibitors of hepatitis C NS3/4A protease. Compound 11a, with an alpha-ethyl P1 substituent and a Boc-valine substituent at the pyrrolidine nitrogen, has an IC(50)=30 microM.
View Article and Find Full Text PDF