Maintenance of Stemlike Glioma Cells and Microglia in an Organotypic Glioma Slice Model.

Background: The therapeutic resistance of gliomas is, at least in part, due to stemlike glioma cells (SLGCs), which self-renew, generate the bulk of tumor cells, and sustain tumor growth. SLGCs from glioblastomas (GB) have been studied in cell cultures or mouse models, whereas little is known about SLGCs from lower grade gliomas.

Objective: To compare cell and organotypic slice cultures from GBs and lower grade gliomas and study the maintenance of SLGCs.

PRODORIC (release 2009): a database and tool platform for the analysis of gene regulation in prokaryotes.

PRODORIC is a database that provides annotated information on the regulation of gene expression in prokaryotes. It integrates a large compilation of gene regulatory data including transcription factor binding sites, promoter structures and gene expression patterns. The whole dataset is manually curated and relies on published results extracted from the scientific literature.