Publications by authors named "Susanne Andi Iversen"
Long-term mortality and health-related quality of life with lower versus higher oxygenation targets in intensive care unit patients with COVID-19 and severe hypoxaemia.
Elena Crescioli Frederik Mølgaard Nielsen Anne-Marie Bunzel Anne Sofie Broberg Eriksen Martin Siegemund Susanne Andi Iversen
Intensive Care Med
October 2024
Article Synopsis
- - The study compared one-year outcomes of lower (8 kPa) and higher (12 kPa) oxygenation targets in ICU patients with COVID-19 and severe hypoxaemia, involving 726 randomly assigned patients.
- - Findings showed that 33.6% of patients in the lower-oxygenation group died, compared to 39.1% in the higher-oxygenation group, suggesting a potential benefit of the lower target, though results were not statistically significant (p = 0.11).
- - Health-related quality of life assessments indicated no significant differences between the two groups, with the lower-oxygenation group having a median EQ-VAS score of 50 vs 40 for the higher group (p
Background: Coronavirus disease (COVID-19) primarily affects the lungs and lower airways and may present as hypoxaemic respiratory failure requiring admission to an intensive care unit (ICU) for supportive treatment. Here, supplemental oxygen remains essential for COVID-19 patient management, but the optimal dosage is not defined. We hypothesize that targeting an arterial partial pressure of oxygen of 8 kPa throughout ICU admission is superior to targeting 12 kPa.
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