Publications by authors named "Susanna Naldi"
The Proviral Integration site for the Moloney murine leukemia virus (PIM)-1 kinase and its family members (PIM-2 and PIM-3) regulate several cellular functions including survival, proliferation, and apoptosis. Recent studies showed their involvement in the pathogenesis of rheumatoid arthritis RA, while no studies are available on psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA). The main objective of this study is to assess the expression of PIM kinases in inflammatory arthritides, their correlation with proinflammatory cytokines, and their variation after treatment with biologic disease-modifying anti-rheumatic drugs or JAK inhibitors.
View Article and Find Full Text PDFResearch biobanks are non-profit structures that collect, manipulate, store, analyze and distribute systematically organized biological samples and data for research and development purposes. Over the recent years, we have established a biobank, the Rheumatology BioBank (RheumaBank) headed by the Medicine and Rheumatology unit of the IRCCS Istituto Ortopedico Rizzoli (IOR) in Bologna, Italy for the purpose of collecting, processing, storing, and distributing biological samples and associated data obtained from patients suffering from inflammatory joint diseases. RheumaBank is a research biobank, and its main objective is to promote large-scale, high-quality basic, translational, and clinical research studies that can help elucidate pathogenetic mechanisms and improve personalization of treatment choice in patients with rheumatoid arthritis (RA), psoriatic arthritis (PsA) and other spondyloarthritides (SpA).
View Article and Find Full Text PDFIntroduction: Obesity can worsen fibromyalgia (FM) and very low-calorie ketogenic diet (VLCKD) is a potential therapeutic option for diseases that share clinical and pathophysiological features with FM. In this pilot interventional study, we investigated the effects of VLCKD in obese women with FM.
Methods: Female patients with FM and a body mass index (BMI) ≥ 30 kg/m were eligible for VLCKD.
As the number of reports of post-acute COVID-19 musculoskeletal manifestations is rapidly rising, it is important to summarize the current available literature in order to shed light on this new and not fully understood phenomenon. Therefore, we conducted a systematic review to provide an updated picture of post-acute COVID-19 musculoskeletal manifestations of potential rheumatological interest, with a particular focus on joint pain, new onset of rheumatic musculoskeletal diseases and presence of autoantibodies related to inflammatory arthritis such as rheumatoid factor and anti-citrullinated protein antibodies. We included 54 original papers in our systematic review.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to deeply analyze macrophage activation syndrome (MAS) in adults with Still's disease by looking at cytokines, inflammation markers, and how multiple organs are affected.
- Researchers collected clinical data and used advanced techniques like Luminex multiplexing and mass cytometry to examine immune cells in AOSD patients, comparing those with and without MAS.
- Results revealed that elevated levels of specific cytokines, along with a distinct immune cell profile, could help differentiate MAS cases, indicating a significant role for IFN-γ and other factors in the inflammatory response associated with the disease.
Article Synopsis
- Prosthetic joint infection (PJI) is a major complication after joint surgeries, and accurately identifying the causal organisms is crucial for effective treatment, with DTT and sonication emerging as potential diagnostic methods.
- A study involving 232 patients compared the effectiveness of DTT and sonication against standard tissue culture methods, finding that both DTT (91%) and sonication (89%) had higher sensitivity than standard cultures (79%).
- DTT was notably more sensitive than sonication and standard cultures when infection was not suspected pre-surgery (100% versus 70% and 50%), but when infection was anticipated, both DTT and sonication did not exceed the sensitivity of standard cultures (89% and 94% vs.