Actinium-225 photonuclear production in nuclear reactors using a mixed radium-226 and gadolinium-157 target.

Background: Actinium-225 is one of the most promising radionuclides for targeted alpha therapy. Its limited availability significantly restricts clinical trials and potential applications of Ac-based radiopharmaceuticals.

Methods: In this work, we examine the possibility of Ac production from the thermal neutron flux of a nuclear reactor.