Publications by authors named "Susann Dornbusch"
Mosquitoes are known to transmit different arthropod-borne viruses belonging to various virus families. The exogenous small interfering RNA pathway plays an important role in the mosquito defence against such virus infections, with Dicer-2 (Dcr2) as one of the key proteins that initiates the cleavage of viral dsRNAs into 21 nt long virus-derived small interfering RNAs. Previous data identified the importance of various motifs in Dcr2 for its small interfering RNA (siRNA)-mediated antiviral activity.
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- Insects that feed on blood, like mosquitoes, use their sense of smell to find hosts, and certain pathogens can change how they smell and behave.
- The study investigates how the Rift Valley Fever Virus (RVFV) impacts the olfactory responses and activity of infected non-biting flies using various tests, confirming RVFV presence through PCR.
- Results show that infected flies have reduced responses to certain odors and lower activity levels shortly after infection, but these effects wear off by days six or seven, even though their immune response genes are still active.
Mosquitoes are vectors of various pathogens that cause diseases in humans and animals. To prevent the outbreak of mosquito-borne diseases, it is essential to control vector populations, as treatment or vaccination for mosquito-borne diseases are often unavailable. Insect-specific viruses (ISVs) have previously been described as being potentially helpful against arboviral disease outbreaks.
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