- The study investigates the pathophysiological pathways linked to neurodevelopmental disorders (ND) in very preterm (VPTN) and extremely preterm newborns (EPTN), aiming to track ND emergence and factors influencing it from birth to age 6.
- It employs a longitudinal, multicenter approach involving two cohorts, assessing over a six-year period to discover urinary metabolomic biomarkers and DNA methylation patterns that could predict ND.
- The findings aim to enhance early identification of clinical, environmental, and biological factors related to ND, potentially leading to non-invasive biomarkers for timely and tailored interventions for affected children.