Publications by authors named "Susana Sancho Chinesta"
Background: Acute respiratory distress syndrome (ARDS) can be classified into sub-phenotypes according to different inflammatory/clinical status. Prognostic enrichment was achieved by grouping patients into hypoinflammatory or hyperinflammatory sub-phenotypes, even though the time of analysis may change the classification according to treatment response or disease evolution. We aimed to evaluate when patients can be clustered in more than 1 group, and how they may change the clustering of patients using data of baseline or day 3, and the prognosis of patients according to their evolution by changing or not the cluster.
View Article and Find Full Text PDFObjective: To validate the unsupervised cluster model (USCM) developed during the first pandemic wave in a cohort of critically ill patients from the second and third pandemic waves.
Design: Observational, retrospective, multicentre study.
Setting: Intensive Care Unit (ICU).
Objective: To evaluate the impact of obesity on ICU mortality.
Design: Observational, retrospective, multicentre study.
Setting: Intensive Care Unit (ICU).
Article Synopsis
- The study investigates the effectiveness of procalcitonin (PCT) and C-reactive protein (CRP) as biomarkers for identifying bacterial coinfection in COVID-19 patients admitted to ICUs in Spain.
- Of 4,076 patients studied, only 3% had bacterial coinfection, and while PCT and CRP showed high negative predictive values, their overall predictive capability was found to be low.
- The findings indicate that measuring PCT and CRP at hospital admission is not a reliable method for diagnosing bacterial coinfection in COVID-19 pneumonia patients.
Purpose: Although there is evidence supporting the benefits of corticosteroids in patients affected with severe coronavirus disease 2019 (COVID-19), there is little information related to their potential benefits or harm in some subgroups of patients admitted to the intensive care unit (ICU) with COVID-19. We aim to investigate to find candidate variables to guide personalized treatment with steroids in critically ill patients with COVID-19.
Methods: Multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish ICUs.
Introduction: The COVID-19 pandemic created tremendous challenges for health-care systems. Intensive care units (ICU) were hit with a large volume of patients requiring ICU admission, mechanical ventilation, and other organ support with very high mortality. The Centro de Investigación Biomédica en Red-Enfermedades Respiratorias (CIBERES), a network of Spanish researchers to investigate in respiratory disease, commissioned the current proposal in response to the Instituto de Salud Carlos III (ISCIII) call.
View Article and Find Full Text PDFBackground: Some patients previously presenting with COVID-19 have been reported to develop persistent COVID-19 symptoms. While this information has been adequately recognised and extensively published with respect to non-critically ill patients, less is known about the incidence and factors associated with the characteristics of persistent COVID-19. On the other hand, these patients very often have intensive care unit-acquired pneumonia (ICUAP).
View Article and Find Full Text PDFCorticosteroid treatment and mortality in mechanically ventilated COVID-19-associated acute respiratory distress syndrome (ARDS) patients: a multicentre cohort study.
Ann Intensive Care
November 2021
Article Synopsis
- The study aimed to evaluate the impact of corticosteroids on ICU mortality in mechanically ventilated COVID-19 patients suffering from ARDS.
- Conducted in 70 ICUs, the study included 1,835 patients, with 1,117 receiving corticosteroids; however, initial results showed no significant difference in ICU mortality between those treated and those untreated with corticosteroids.
- While corticosteroid treatment appeared to provide short-term survival benefits, it led to increased ICU mortality after 17 days, particularly benefiting younger patients and those with severe ARDS.
Background: Mortality due to COVID-19 is high, especially in patients requiring mechanical ventilation. The purpose of the study is to investigate associations between mortality and variables measured during the first three days of mechanical ventilation in patients with COVID-19 intubated at ICU admission.
Methods: Multicenter, observational, cohort study includes consecutive patients with COVID-19 admitted to 44 Spanish ICUs between February 25 and July 31, 2020, who required intubation at ICU admission and mechanical ventilation for more than three days.
Deploying unsupervised clustering analysis to derive clinical phenotypes and risk factors associated with mortality risk in 2022 critically ill patients with COVID-19 in Spain.
Crit Care
February 2021
Background: The identification of factors associated with Intensive Care Unit (ICU) mortality and derived clinical phenotypes in COVID-19 patients could help for a more tailored approach to clinical decision-making that improves prognostic outcomes.
Methods: Prospective, multicenter, observational study of critically ill patients with confirmed COVID-19 disease and acute respiratory failure admitted from 63 ICUs in Spain. The objective was to utilize an unsupervised clustering analysis to derive clinical COVID-19 phenotypes and to analyze patient's factors associated with mortality risk.