Macrophage Activation Syndrome Secondary to Histoplasmosis in an Adult Female Carrier of X-linked Chronic Granulomatous Disease with Extreme Lyonization.

not applicable to a Letter to the Editor.

[IgE deficiency: a forgotten disease?].

Background: Selective IgE deficiency is a profound deficiency (< 5 UI/mL) or absence of serum IgE levels without other immunologic abnormalities. It is usually asymptomatic, but may be associated with recurrent respiratory infections, chronic fatigue, and musculoskeletal complaints.

Objective: To describe the evolution and treatment in patients with selective IgE deficiency.

[Allergic disease with IgE hypersynthesis. Proposal of a new denomination for an allergic disease confused with immunodeficiency].

Within the variety of diseases in which there is an excessive production of immunoglobulin E (IgE), clinicians have the dilemma to establish a differential diagnosis between allergy, immunodeficiency and even autoimmunity. In the present study the clinical manifestations of allergic patients who presented very high levels of IgE and who were taken care of in the Allergy Service of the National Institute of Pediatrics and did not show criteria to be identified as carriers of some non-atopic immunological disease (eg. Hyper-IgE syndrome), are described.