Structure-Activity Relationship of Natural Dihydrochalcones and Chalcones, and Their Respective Oxyalkylated Derivatives as Anti- Agents.

sp. is a pathogenic oomycete responsible for severe economic losses in aquaculture. To date, there is no treatment for its control that is effective and does not pose a threat to the environment and human health.

In Vitro Antifungal Activity and Toxicity of Dihydrocarvone-Hybrid Derivatives against .

The aim of this study was to synthesize a series of novel and known dihydrocarvone-hybrid derivatives (-) and to evaluate mycelial growth activity of hybrid molecules against two strains of , as well as their toxicity. Dihydrocarvone-hybrid derivatives have been synthesized under sonication conditions and characterized by FTIR, NMR, and HRMS. Antifungal efficacy against both strains of was determined by half maximal effective concentration (EC) and toxicity using the brine shrimp lethality test (BSLT).

Ultrasound assisted synthesis and cytotoxicity evaluation of known 2',4'-dihydroxychalcone derivatives against cancer cell lines.

This work reports on the development of an efficient and ecofriendly ultrasound assisted method for the high yield synthesis (70.0-94.0%) of eighteen oxyalkylated derivatives of 2',4'-dihydroxychalcone.

Antioxidant and Anti-Proliferative Activity of Essential Oil and Main Components from Leaves of Harvested in Central Chile.

The aim of this study was to determine, first, the chemical composition of (Griseb) Moldenke essential oil, from leaves harvested in central Chile; and second, its antioxidant and cytotoxic activity. Eight compounds were identified via gas chromatography-mass spectrometry (GC-MS) analyses, with the most representative being -carvone (91.03%), -limonene (4.

Structure-Activity Relationship of Dialkoxychalcones to Combat Fish Pathogen .

To investigate the anti- activities of chalconic compounds, nine dialkoxychalcones ⁻, along with their key building block 2',4'-dihydroxychalcone , were evaluated for their potential oomycide activities against strains. The synthesis afforded a series of -alkylated derivatives with typical chalcone skeletons. Compounds ⁻ were reported for the first time.

Synthesis and Evaluation of Novel Oxyalkylated Derivatives of 2',4'-Dihydroxychalcone as Anti-Oomycete Agents against Bronopol Resistant Strains of Saprolegnia sp.

A series of novel oxyalkylchalcones substituted with alkyl groups were designed and synthesized, and the antioomycete activity of the series was evaluated in vitro against Saprolegnia strains. All tested O-alkylchalcones were synthesized by means of nucleophilic substitution from the natural compound 2',4'-dihydroxychalcone (1) and the respective alkyl bromide. The natural chalcone (1) and 10 synthetic oxyalkylchalcones (2-11) were tested against Saprolegnia parasitica and Saprolegnia australis.

Evaporation dynamics of microdroplets on self-assembled monolayers of dialkyl disulfides.

We present a study of the static wettability and evaporation dynamics of sessile microdroplets of water on self-assembled monolayers (SAMs) prepared with unsymmetric dialkyl disulfides CH(3)-(CH(2))(11+m)-S-S-(CH(2))(11)-OH (m = 0, +/- 2, +/- 4, +/- 6) on gold-covered mica. The advancing and receding contact angles decrease linearly with increasing hydrophilicity of the SAM. The latter was changed either via the molar ratio or via the chain length of the hydroxyl-terminated alkyl chains in the monolayer.

Applying the mental models framework to carbon monoxide risk in northern Mexico.

Objectives: Low-income residents of northern Mexico rely on unvented heaters during the winter, a practice that puts them at elevated risk for carbon monoxide intoxication. The goal of this study is to develop a communication protocol for carbon monoxide intoxication risks among the primarily low socioeconomic status population of Ciudad Juárez, Chihuahua, Mexico.

Methods: The mental models risk communication approach was used to identify important gaps in public understanding.