Publications by authors named "Susana Escandar"
Article Synopsis
- The study aimed to assess the prevalence of clarithromycin and metronidazole resistance in Helicobacter pylori from patients in Santiago, Chile, utilizing molecular methods on DNA samples from gastric mucosa.
- Out of 191 DNA samples tested, 93 were positive for H.pylori, with 31.2% showing clarithromycin resistance; mutations linked to metronidazole resistance were also identified in various samples.
- The findings suggest a significant prevalence of antibiotic resistance in the region, highlighting the need to reconsider existing treatment guidelines for H.pylori eradication in Chile.
Aim: To assess the role of pro- and anti-inflammatory polymorphisms in gastric cancer susceptibility.
Patients And Methods: We genotyped 12 polymorphisms in eight cytokine genes (Interleukin-1β -IL1B-, IL8, IL17A, IL17F, IL32, tumor necrosis factor-α -TNF-, IL1RN, IL10) in a case-control study of 147 patients with gastric cancer and 172 controls.
Results: Single polymorphism analysis revealed an association between the IL10 -592C>A single nucleotide polymorphism and cases with moderately- or well-differentiated tumors [AA vs.