Photoletter to the editor: Localized pyoderma gangrenosum after interferon-alpha2b injections.

We present a male patient with polycythemia vera (PV) in whom pyoderma gangrenosum (PG) was induced by subcutaneous injections of interferon-α2beta (IFN-α2b).The patient presented with a 6 cm wide necrotic ulcer on the external aspect of his left thigh, which was surrounded by an erythematous and indurated plaque. He also had a simetrical but smaller 2 cm of size ulcer on the external aspect of the right thigh.

Circumscribed palmar hypokeratosis associated with disseminated superficial actinic porokeratosis.

Circumscribed palmar and plantar hypokeratosis (CPPH) is a recently described skin condition with particular clinical and histopathological findings. The etiopathogeny of CPPH is still unclear, but an abnormal clone of keratinocytes has been postulated as the possible origin. CPPH has been considered an entity with no potential malignant transformation, but recently, it has been recognized in association with signs of actinic keratosis in the same biopsy.

Familial poikylodermic cutaneous amyloidosis.

Among the less common variants of primary cutaneous amyloidosis are both the poikylodermic and the familial types. The case of two sisters of thirteen and seventeen years old with extensive asymptomatic lesions with a poikylodermic aspect is reported. The girls' father was also affected and a paternal aunt had consulted at our department some years previously for similar lesions.