Acute Carpal Tunnel Syndrome Secondary to Gout Flare and Outcomes at 18 Months After Open Carpal Tunnel Decompression.

Acute carpal tunnel syndrome is a rare condition that requires immediate surgery. Although numerous causes have been described in the literature, only 7 reports of acute carpal tunnel syndrome secondary to gout have been reported, all with short follow-ups. We report, to our knowledge, the first case of carpal tunnel syndrome presenting with total anesthesia of the fingers innervated by the median nerve and complete recovery of the sensory and motor function after carpal tunnel decompression, with no recurrence at the 18-month follow-up.

Development, characterization and in vitro evaluation of single or co-loaded imatinib mesylate liposomal formulations.

Mitoxantrone-based combinations are a standard palliative treatment in hormone-refractory prostate cancer (HRPC) but with no survival benefit. Imatinib has shown preclinical activity against HRPC although minimal clinical therapeutic efficacy. Our previous in vitro studies demonstrated that simultaneous combination of imatinib with mitoxantrone yielded additive growth inhibition effects against PC-3 cell line.

Schedule treatment design and quantitative in vitro evaluation of chemotherapeutic combinations for metastatic prostate cancer therapy.

Purpose: Preclinical evaluation is essential for a rational design of combination chemotherapy as some agents, with known mechanisms of action and non-overlapping toxicities may increase the therapeutic index of anticancer drugs, whose clinical success is hindered by side effects and drug resistance. The present study investigated new drug combinations with potential outcome for the treatment of metastatic prostate cancer. This final clinical stage exhibits predominantly hormone-refractory prostate cancer (HRPC) cells but also a minority of hormone responsive cells.