Epidemiology of mechanical ventilation: analysis of the SAPS 3 database.

Objective: To evaluate current practice of mechanical ventilation in the ICU and the characteristics and outcomes of patients receiving it.

Design: Pre-planned sub-study of a multicenter, multinational cohort study (SAPS 3).

Patients: 13,322 patients admitted to 299 intensive care units (ICUs) from 35 countries.

Modeling in-hospital patient survival during the first 28 days after intensive care unit admission: a prognostic model for clinical trials in general critically ill patients.

Objective: The objective of the study was to develop a model for estimating patient 28-day in-hospital mortality using 2 different statistical approaches.

Design: The study was designed to develop an outcome prediction model for 28-day in-hospital mortality using (a) logistic regression with random effects and (b) a multilevel Cox proportional hazards model.

Setting: The study involved 305 intensive care units (ICUs) from the basic Simplified Acute Physiology Score (SAPS) 3 cohort.