Lifetime Pain Management Experiences of Female Breast Cancer Survivors Aged 65+ Years.

Purpose: Explore factors influencing pain management among female breast cancer survivors aged 65+ years with moderate to severe pain based on a score of 4 or greater on the 0-10 numeric rating scale.

Design: Qualitative descriptive study.

Methods: We interviewed 21 purposefully sampled women aged 65+ years who experienced moderate to severe pain.

Psychoneurological symptom cluster trajectories in individuals treated for early-stage breast cancer.

Background/purpose: The psychoneurological (PN) symptom cluster has been defined in the literature as anxiety, depression, fatigue, sleep disturbance, and pain. PN symptoms are influenced by cancer and its treatment as well as biological and psychosocial factors. The purpose of this analysis was to describe temporal patterns of the PN symptom cluster severity in breast cancer survivors over the year following initial surgical intervention and investigate the time-dependent effect of treatment modality on symptom severity.

Postdischarge Nausea and Vomiting and Co-occurring Symptoms in Women Following Breast Cancer Surgery.

Purpose: The purpose of this study was to investigate the influence of potential co-occurring symptoms, including fatigue, sleep disturbance, anxiety, depressive symptoms, and pain, on the incidence of postdischarge nausea (PDN) measured two days following discharge to home after surgery for breast cancer.

Design: This study used a prospective, cross-sectional, observational design.

Methods: The sample was 334 women aged 27 to 88 years of age.

The Cancer Genomic Integration Model for Symptom Science (CGIMSS): A Biopsychosocial Framework.

Current nursing research has characterized symptom clusters and trajectories in individuals with breast cancer. The existing literature describes the relationship between symptoms and biological variables and the potential moderating effects of individual and social factors. The genomic profiling of breast cancer has also been an area of much recent research.

Oncology Nurses' Role in Promoting Patient Self-Advocacy.

Teaching patients with cancer the skill of self-advocacy shifts the focus of their cancer care onto what is important to them, leading to optimized patient-centered care. As oncology nurses, providing support to patients as they self-advocate to get their needs met fosters a collaborative relationship, creating an environment in which patients feel comfortable verbalizing their needs and concerns.

Factors associated with sleep disturbances in women undergoing treatment for early-stage breast cancer.

Purpose: The purpose of this study was to examine factors associated with sleep disturbance in women receiving adjuvant therapy for breast cancer.

Methods: This study employed a cross-sectional design using data collected at 3 months post-surgery from an ongoing longitudinal parent study. Participant data were divided into adjuvant treatment groups (chemotherapy, radiation, and aromatase inhibitors) and no adjuvant treatment groups.

Older Women and Opioid Analgesia after Breast Cancer Surgery.

Purpose: To explore which factors influence opioid analgesia use in older women during the 48-hour period after hospital discharge following initial breast cancer surgery.

Design: This cross-sectional, descriptive study involved a cohort (n = 57) of older women recruited for a larger study of breast cancer patients.

Methods: We gathered patient-reported data pertinent to perioperative and post-discharge pain control.

Symptom Science: Omics and Response to Non-Pharmacological Interventions.

Incorporating omics into non-pharmacological intervention research design could provide a better understanding of the variability in response to these interventions. It would also provide evidence for precision-based non-pharmacological interventions, including interventions focused on symptoms. The purpose of this manuscript was to present examples of studies that have used omics to examine response to non-pharmacological intervention.

Integrative Review of Reproductive Decision Making of Women Who Are BRCA Positive.

Objective: To synthesize research findings about reproductive decision making among women who are BRCA positive.

Data Sources: PubMed and CINAHL.

Study Selection: Articles published in English between 2000 and June 28, 2020, about the reproductive decision making of women with a confirmed BRCA1 or BRCA2 mutation.

Research Agenda of the Oncology Nursing Society: 2019-2022.

Problem Statement: To define the Oncology Nursing Society Research Agenda for 2019-2022.

Design: Multimethod, consensus-building approach by members of the Research Agenda Project Team.

Data Sources: Expert opinion, literature review, surveys, interviews, focus groups, town hall, and review of research priorities from other cancer care organizations and funding agencies.

Examining the effect of 5-HTTLPR on depressive symptoms in postmenopausal women 1 year after initial breast cancer treatment.

Background: Depression following the diagnosis of breast cancer has been well documented, and occurs in as many as 40% of women. The serotonin transporter gene SLC6A4 and its functional polymorphism 5-HTTLPR have been extensively studied as factors in the development of depression. Many research studies have demonstrated conflicting results, and the contribution of 5-HTTLPR to depression is unclear.

The Relationship of Age and Postoperative Pain in Women after Surgery for Breast Cancer.

Background: In the past, elderly women with breast cancer were not offered surgery because of beliefs that they would experience serious complications from comorbidities and increased chronological age. Today the decision to offer surgery is based on a woman's fitness rather than her age.

Objective: The purpose of this study is to compare the experience of postoperative nausea and vomiting (PONV), anxiety, and reported pain levels in women who represent four different age groups after breast cancer surgery.

Symptom Science: Omics Supports Common Biological Underpinnings Across Symptoms.

For precision health care to be successful, an in-depth understanding of the biological mechanisms for symptom development and severity is essential. Omics-based research approaches facilitate identification of the biological underpinnings of symptoms. We reviewed literature for omics-based approaches and exemplar symptoms (sleep disruption, cognitive impairment, fatigue, gastrointestinal [GI] distress, and pain) to identify genes associated with the symptom or symptoms across disease processes.

A Prospective Study of Nausea and Vomiting After Breast Cancer Surgery.

Purpose: Postoperative nausea and vomiting (PONV) and post-discharge nausea and vomiting (PDNV) continue to be common and disturbing complications experienced after surgery, particularly in women and especially in women undergoing breast cancer surgery. The purpose of this study was to assess the incidence and risk factors associated with PONV and PDNV from preoperative to 48 hours postoperatively in 97 women scheduled for breast cancer surgery.

Design: Prospective, comparative design.

Managing Symptoms: Enhancing Patients Self-Management Knowledge and Skills for Surgical Recovery.

Objectives: To review postoperative symptoms experienced by patients following surgery for cancer and discuss focused, evidenced-based methods to teach the patient acute pain and symptom management to include both pharmacological and non-pharmacological strategies.

Data Sources: Peer reviewed articles and national guidelines.

Conclusion: Although significant advances have been made in providing effective acute pain control, pain remains a serious consequence after cancer surgery.

Primer in Genetics and Genomics, Article 1: DNA, Genes, and Chromosomes.

Precision medicine refers to the practice of determining a patient's unique genetic, biomarker, and other characteristics for the purpose of improving his or her clinical outcomes. Not all patients with the same clinical diagnosis respond equally to identical treatment regimens. By examining patients at the molecular level, health-care providers will be better able to apply the most effective therapies that each individual requires.

Exploring the multifactorial nature of postoperative nausea and vomiting in women following surgery for breast cancer.

Background: Postoperative nausea and vomiting (PONV) are two of the most frequent and distressing complications following surgical procedures, with as many as 80% of patients considered to be at risk. Despite recognition of well-established risk factors and the subsequent use of clinical guidelines, 20-30% of women do not respond to antiemetic protocols, indicating that there may be a genetic risk.

Objective: The purpose of this pilot study was to describe the incidence and explore the risk factors associated with PONV after surgery in women diagnosed with early stage breast cancer.

Beyond BRCA: A Pilot Program to Assess and Improve Knowledge of Pharmacogenomic Testing Among Advanced Practitioners in a Breast Cancer Treatment Setting.

To provide the best available evidence-based care to their patients, advanced practitioners (APs) must become proficient in genomic competencies and remain informed regarding the availability of pharmacogenomic tests. Databases, such as the Centers for Disease Control and Prevention's "Genomic Testing," provide guidance about pharmacogenomic testing, but many APs are not aware of these resources. This study employed a quasi-experimental pretest/posttest design using a convenience sample of APs in a large clinical outpatient breast cancer clinic to assess the knowledge base, beliefs, attitudes, and barriers regarding pharmacogenomic testing among front-line APs and increase knowledge through a targeted educational intervention.

Association between serotonin transport polymorphisms and postdischarge nausea and vomiting in women following breast cancer surgery.

Purpose/objectives: To examine the association of the serotonin transport gene and postdischarge nausea and vomiting (PDNV) in women following breast cancer surgery.

Design: A cross-sectional study.

Setting: A comprehensive cancer center in Pittsburgh, PA.

Priorities for oncology nursing research: the 2013 national survey.

Purpose/objectives: To advance the goals of evidence-based care and prioritize the knowledge generation that addresses contemporary challenges in oncology nursing. Results are used to inform the development of the Oncology Nursing Society (ONS) Research Agenda and by the ONS Foundation to develop strategic research initiatives.

Design: Descriptive, cross-sectional survey.

The association of CYP2D6 genotype and postoperative nausea and vomiting in orthopedic trauma patients.

The CYP2D6 gene encodes for an enzyme that is involved in the metabolism of more than 25% of all medications, including many opioids and antiemetics. It may contribute to the risk of postoperative nausea and vomiting (PONV), a common surgical complication. However, little research has been conducted in this area.

Critical thinking ability of new graduate and experienced nurses.

Aim: This paper is a report of a study to identify critical thinking learning needs of new and experienced nurses.

Background: Concern for patient safety has grown worldwide as high rates of error and injury continue to be reported. In order to improve patient safety, nurses must be able to recognize changes in patient condition, perform independent nursing interventions, anticipate orders and prioritize.