Expanding the Biotherapeutics Realm via miR-34a: "Potent Clever Little" Agent in Breast Cancer Therapy.

Background: One of the most prevalent cancers befell to women is considered to be breast cancer (BC). It is also the deadliest among the female population after lung cancer. Additionally, several studies have demonstrated that there is an association between microRNA34-a and breast cancer.

Determination of ammonia by designing an optode based on immobilization of a Co(III)-Schiff base complex on a triacetylcelluose membrane.

A novel ammonia optode was designed using [4-methyl-N,N'-bis(salicylidene)-1,2-phenylenediamine] tributylphosphincobalt(III) perchlorate monohydrate [Co(4-MeSaloph)(PBu)3]+ complex coated on a triacetylcellulose membrane. The sensor could be used at a wavelength of 378 nm to detect ammonia in the range of 8.3 x 10(-4) and -1.

Synthesis, characterization, and thermodynamics of some new unsymmetrical Schiff bases of salicylaldehyde with 3,4-diaminopyridine and their cobalt(III) complexes.

Some new Schiff bases derived from 3,4-diaminopyridine (3,4-DAP) and their new unsymmetrical Co(III) five coordinate complexes described as [Co(Chel)(L)]ClO4⋅H2O where (Chel) is the deprotonated form of a series of unsymmetric ligands containing 3,4-diaminopyridine (3,4-DAP) and substituted salicylaldehyde moieties and a new Co(III) six coordinate Co(III) complex, were synthesized and characterized by (1)H NMR, IR, UV-Vis, and elemental analysis. For the new synthesized five coordinate complexes, the formation constants of the interaction of the Co(III) Schiff bases with various donors were measured spectrophotometrically. The trend of the formation constants of the five coordinate Co(III) Schiff base complexes toward a given phosphine is as follow: 5-H>5-Br and the formation constants trend of these donors are as follow: PBu3>PPh2Me.

Synthesis, characterization and thermodynamics of complex formation of some new Schiff base ligands with some transition metal ions and the adduct formation of zinc Schiff base complexes with some organotin chlorides.

Four new complexes, [M(Salpyr)] where Salpyr=N,N'-bis(Salicylidene)-2,3- and 3,4-diiminopyridine and M=Co, Cu, Mn, Ni and Zn were synthesized and characterized by (1)H NMR, IR spectroscopy, elemental analysis and UV-vis spectrophotometry. UV-vis spectrophotometric study of the adduct formation of the zinc(II) complexes, [Zn(2,3-Salpyr)] and [Zn(3,4-Salpyr)], as donor with R(2)SnCl(2) (R=methyl, phenyl, n-butyl), PhSnCl(3) and Bu(3)SnCl as acceptors has been investigated in methanol, as solvent. The formation constants and the thermodynamic free energies were measured using UV-vis spectrophotometry.