Multiple eruptive squamous cell carcinoma in a patient with chronic plaque psoriasis on adalimumab.

A 67-year-old man with chronic plaque psoriasis previously treated with psoralen plus PUVA, ciclosporin, methotrexate and acitretin developed eruptive squamous cell carcinoma after seven doses of adalimumab. We review the association of squamous cell carcinoma with immunosuppressive agents used for the treatment of chronic plaque psoriasis. Initiation of tumour necrosis factor (TNF)-α inhibitors in a patient at high risk of non-melanoma skin cancer may warrant chemoprophylaxis with acitretin.

A puzzling case: SCC or not?

We present a 37-year-old woman who underwent extensive facial surgery for removal of multiple eruptive squamous cell carcinoma (SCC)-like lesions resembling invasive SCC histologically. The patient's mother had undergone numerous surgical procedures and radiotherapy for facial SCC. A review of the histology and immunohistochemistry for DNA mismatch repair proteins excluded Muir-Torre syndrome.

Clinical review of 202 patients with vulval lichen sclerosus: A possible association with psoriasis.

Two hundred and two patients with clinically typical or biopsy-confirmed vulval lichen sclerosus were reviewed either at consultation (75%) or by retrospectively examining their chart. At diagnosis, 79% were 50 years or older. Ninety-six per cent complained of itching, pain and/or dyspareunia.