Publications by authors named "Susan Schram"
Malignant histiocytosis (MH) is an extremely rare neoplasm of the macrophage-dendritic cell lineage. We report the clinical characteristics, molecular aberrations, treatments, and outcomes of patients with MH seen at two referral centers from January 2000 to May 2023. We identified 43 patients with MH, of which 26 had histiocytic sarcoma (MH-H), 9 interdigitating dendritic cell sarcoma (MH-IDC), and 8 Langerhans cell sarcoma (MH-LC).
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- - The study analyzed 156 adults with Langerhans cell histiocytosis to see if BRAF mutation status affected disease severity or survival rates, finding no significant correlation.
- - It was noted that BRAFV600E mutations were linked to a higher occurrence of second cancers, particularly hematological types, in patients.
- - These second malignancies may share a common origin with the original condition, suggesting potential connections between them.
Article Synopsis
- - Understanding histiocytic disorders has improved due to the identification of MAPK pathway mutations, especially BRAFV600E, but there's uncertainty about the best methods for testing these mutations.
- - A review of 120 patients revealed that various testing methods, including immunohistochemistry (IHC), polymerase chain reaction (PCR), and next-generation sequencing (NGS), were used, with NGS serving as the gold standard for accuracy comparison.
- - The study found that while IHC was very specific in detecting BRAFV600E, it had limitations, including some false negatives; thus, the authors recommend using IHC for initial screening followed by molecular testing if results are negative.
Elevated Serum Lactate in Patients With Lymphoma: It Is Not Always Infection.
Mayo Clin Proc Innov Qual Outcomes
April 2021
Article Synopsis
- The study aimed to figure out if patients with lymphoma in the hospital were suffering from sepsis or worsening lymphoma when they had high lactic acid levels.
- Researchers looked at 51 patients and found that most (65%) had sepsis, while the rest (35%) had worsening lymphoma; they tested their blood levels for important signs.
- The results showed that higher levels of a protein called LDH could help doctors tell the difference between the two conditions and should be checked in all lymphoma patients with high lactic acid.