Primary outcome switching among drug trials with and without principal investigator financial ties to industry: a cross-sectional study.

Objectives: To determine the relationship between manufacturer-related financial ties among investigators of published drug trials and rates of discrepant registered and published primary trial outcomes.

Design: Cross-sectional study.

Setting: Human subjects drug trials published in 'core clinical' MEDLINE journals in 2013.

Financial ties of principal investigators and randomized controlled trial outcomes: cross sectional study.

Objective:  To examine the association between the presence of individual principal investigators' financial ties to the manufacturer of the study drug and the trial's outcomes after accounting for source of research funding.

Design:  Cross sectional study of randomized controlled trials (RCTs).

Setting:  Studies published in "core clinical" journals, as identified by Medline, between 1 January 2013 and 31 December 2013.

Common Reasons That Asymptomatic Patients Who Are 65 Years and Older Receive Carotid Imaging.

Importance: National guidelines do not agree on the role of carotid screening in asymptomatic patients (ie, patients who have not had a stroke or transient ischemic attack). Recently, several physician organizations participating in the Choosing Wisely campaign have identified carotid imaging in selected asymptomatic populations as being of low value. However, the majority of patients who are evaluated for carotid stenosis and subsequently revascularized are asymptomatic.