Publications by authors named "Susan Q Ke"
Article Synopsis
- Genomic sequencing helps doctors find the best cancer treatments, but for some brain tumors called ependymomas, the causes are still unclear and there aren’t good treatment options.
- Ependymomas are tough to treat, especially the more aggressive type found in young children, called posterior fossa ependymoma group A (PF-EPN-A), which doesn’t have many genetic changes, while another type (PF-EPN-B) shows some genetic changes but tends to respond well to treatment.
- Researchers studied 42 ependymoma samples to find specific genes and pathways that are important for the tumor cells, which could lead to new treatment strategies that help kill the cancer and improve survival in lab tests.
The blood-tumor barrier (BTB) is a major obstacle for drug delivery to malignant brain tumors such as glioblastoma (GBM). Disrupting the BTB is therefore highly desirable but complicated by the need to maintain the normal blood-brain barrier (BBB). Here we show that targeting glioma stem cell (GSC)-derived pericytes specifically disrupts the BTB and enhances drug effusion into brain tumors.
View Article and Find Full Text PDFGlioblastoma multiforme (GBM) is the most lethal brain tumor. Tumor relapse in GBM is inevitable despite maximal therapeutic interventions. Glioma stem cells (GSCs) have been found to be critical players in therapeutic resistance and tumor recurrence.
View Article and Find Full Text PDFTumour-associated macrophages (TAMs) are enriched in glioblastoma multiformes (GBMs) that contain glioma stem cells (GSCs) at the apex of their cellular hierarchy. The correlation between TAM density and glioma grade suggests a supportive role for TAMs in tumour progression. Here we interrogated the molecular link between GSCs and TAM recruitment in GBMs and demonstrated that GSCs secrete periostin (POSTN) to recruit TAMs.
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