Publications by authors named "Susan P Bennett"
Article Synopsis
- Langerhans cells (LCs) are crucial for skin immunity, and their loss under UV radiation (UVR) weakens immune responses.
- Omega-3 fatty acids, particularly eicosapentaenoic acid (EPA), are explored for their potential to counteract this suppression, but a study found that EPA did not significantly impact LCs or inflammatory markers in response to UVR.
- UVR exposure reduced the levels of the immunomodulatory mediator prostaglandin D (PGD) in skin, indicating possible implications for skin disease treatment, despite a lack of EPA effectiveness in restoring LC numbers.
Background: Skin cancer is a major public health concern, and the majority of cases are caused by solar ultraviolet radiation (UVR) exposure, which suppresses skin immunity. Omega-3 (n-3) PUFAs protect against photoimmunosuppression and skin cancer in mice, but the impact in humans is unknown.
Objectives: We hypothesized that EPA-rich n-3 PUFA would abrogate photoimmunosuppression in humans.