Excess BMI Accelerates Islet Autoimmunity in Older Children and Adolescents.

Objective: Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive relatives without diabetes of patients. We tested whether elevated BMI also accelerates the progression of islet autoimmunity before T1D diagnosis.

Research Design And Methods: We studied 706 single autoantibody-positive pediatric TrialNet participants (ages 1.

Excess BMI in Childhood: A Modifiable Risk Factor for Type 1 Diabetes Development?

Objective: We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth.

Research Design And Methods: We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index.