Objective: To elucidate why diabetes is so difficult to treat despite the present tools and pharmacologic armamentarium and to provide insights into emerging therapies by describing human and rodent data that demonstrates the ability to transform progenitor cells within the adult pancreas into new islets.
Methods: A literature review focused on the distinctions between human and rodent islets.
Results: We are beginning to elucidate important differences between the architecture and composition of the islets of Langerhans in humans and rodents.