Hemodynamic studies of platelet thrombosis using microfluidics.

Platelets contribute to thrombus formation in a variety of ways. Platelet adhesion, activation, and thrombus growth depend greatly on the type of hemodynamic environment surrounding an inciting event. Microfluidic systems may be used to explore these relationships.

Choice of a hemodynamic model for occlusive thrombosis in arteries.

Intravascular thrombosis can lead to heart attacks and strokes that together are the leading causes of death in the US (Kochanek, K.D., Murphy, S.

Sources of Circuit Thrombosis in Pediatric Extracorporeal Membrane Oxygenation.

Extracorporeal membrane oxygenation (ECMO) for cardiopulmonary support of critically ill patients is used frequently in the pediatric population. ECMO is burdened by complications, including thrombosis and hemorrhage. Here we demonstrate the focused location of clots, their histologic composition, and the relationship of in situ thrombus to local hemodynamics in ECMO circuits.

Thrombosis in centrifugal pumps: location and composition in clinical and in vitro circuits.

Purpose: Extracorporeal membrane oxygenation (ECMO) is a form of cardiopulmonary mechanical life support for critically ill patients. ECMO is burdened by both thrombotic and hemorrhagic complications. Recently there has been a clinical shift from roller pumps to centrifugal pumps.