Dexmedetomidine pharmacokinetics in pediatric intensive care--a pooled analysis.

Background: Published dexmedetomidine pharmacokinetic studies in children are limited by participant numbers and restricted pathology. Pooling the available studies allows investigation of covariate effects.

Methods: Data from four studies investigating dexmedetomidine pharmacokinetics after i.

Pharmacokinetics of dexmedetomidine in postsurgical pediatric intensive care unit patients: preliminary study.

Objective: To characterize the pharmacokinetics of dexmedetomidine and monitor any dexmedetomidine-related adverse events in postoperative pediatric patients requiring short-term mechanical ventilation, analgesia, and sedation in the pediatric intensive care unit (PICU).

Design: Prospective, case series.

Setting: Operating room and PICU in a large, urban children's hospital.

Detection of traumatic brain injury with magnetic resonance imaging and S-100B protein in children, despite normal computed tomography of the brain.

Objective: The objective of this study was to obtain data to further define the extent of traumatic brain injury by using S-100B protein and standard noncontrast magnetic resonance imaging with added fluid-attenuated inversion recovery (FLAIR) and gradient echo sequence in children with normal head computed tomography.

Design: Pilot, single cohort, prospective, clinical diagnostic study.

Setting: Pediatric intensive care and intermediate care unit in a tertiary care children's hospital.