Publications by authors named "Susan Louise Ashrafzadeh-Kian"
The effect of burosumab on intact and C-terminal FGF23 measurements.
Clin Endocrinol (Oxf)
August 2023
Article Synopsis
- The study examines how the drug CRYSVITA® (burosumab) affects the measurement of FGF23 levels using two different assays, finding that only the intact FGF23 assay experiences negative interference from the drug.
- Despite this interference, both assays showed a significant increase in FGF23 levels after treatment with burosumab in patients, indicating high in vivo concentrations.
- The results suggest that when interpreting FGF23 measurements after burosumab treatment, clinicians should consider the interference in the intact assay and assess each patient's overall clinical context and biomarkers.