Publications by authors named "Susan L Grant"
Article Synopsis
- The study investigates the role of gp130 signaling in the regulation of VEGF (vascular endothelial growth factor) in human cardiac myocytes, highlighting the importance of these signals in heart repair and blood vessel development.
- Human adult cardiac myocytes were isolated and treated with different gp130 ligands (CT-1, IL-6, LIF, or OSM) to examine their effects on VEGF production, with OSM showing a significant dose-dependent increase in VEGF production.
- Results revealed that OSM was the primary gp130 ligand responsible for stimulating VEGF-1 production in human cardiac myocytes, supported by the presence of specific receptors for OSM and gp130 in these cells.
Oncostatin M (OSM), an interleukin-6 type cytokine, acts via the gp130 signaling receptor to inhibit proliferation and induce differentiation of breast cancer cells. EGF, a mitogen for breast cells, signals via EGFR/ErbB tyrosine kinase receptors which are implicated in breast cancer pathogenesis. Here we show paradoxically that EGF enhanced the OSM-induced inhibition of proliferation and induction of cellular differentiation in both estrogen receptor positive and negative breast cancer cells.
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