Publications by authors named "Susan L Ashrafzadeh Kian"
Background: It is known that the heavy metals cobalt and chromium are associated with neurotoxicity. Chromium (Cr) and Cobalt (Co) are both components of metal-on-metal (MoM) implants which can be degraded/fragmented and released into the bloodstream. Neurofilament Light Chain (NfL) is a neuron-specific protein that increases in serum following axonal damage.
View Article and Find Full Text PDFThe effect of burosumab on intact and C-terminal FGF23 measurements.
Clin Endocrinol (Oxf)
August 2023
Article Synopsis
- The study examines how the drug CRYSVITA® (burosumab) affects the measurement of FGF23 levels using two different assays, finding that only the intact FGF23 assay experiences negative interference from the drug.
- Despite this interference, both assays showed a significant increase in FGF23 levels after treatment with burosumab in patients, indicating high in vivo concentrations.
- The results suggest that when interpreting FGF23 measurements after burosumab treatment, clinicians should consider the interference in the intact assay and assess each patient's overall clinical context and biomarkers.
Background: Hyperphosphatemia confers adverse cardiovascular outcomes, and commonly occurs in late-stage CKD. Fibroblast growth factor 7 (FGF7) is a phosphaturic peptide which decreases renal phosphate transport in vitro and in vivo. Serum FGF7 concentrations are reduced in hyperphosphatemic patients with hypophosphatasia and are elevated in some hypophosphatemic patients with tumor-induced osteomalacia.
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