Cognitive enhancement therapy for early-course schizophrenia: effects of a two-year randomized controlled trial.

Objective: The early application of cognitive rehabilitation may afford long-term functional benefits to patients with schizophrenia. This study examined the two-year effects of an integrated neurocognitive and social-cognitive rehabilitation program, cognitive enhancement therapy (CET), on cognitive and functional outcomes in early-course schizophrenia.

Methods: Early-course outpatients (mean+/-SD illness duration=3.