Publications by authors named "Susan Hannagan"
Article Synopsis
- Six cases of serogroup B meningococcal disease were reported among individuals who had received either the MenB-4C or MenB-FHbp vaccines in the U.S. since their availability.
- All cases were investigated through health records and whole genome sequencing, revealing that most patients were at higher risk due to either outbreaks or pre-existing medical conditions.
- Factors such as incomplete vaccination, waning immunity, and strain resistance to vaccine-induced serum bactericidal activity (SBA) played significant roles in the occurrence of these cases.
Introduction: This analysis evaluates trends in cervical lesions with human papillomavirus 16/18 detected by area-based measures of race, ethnicity, and poverty during 2008-2015.
Methods: Trends in the proportion of lesions with human papillomavirus 16/18 detected among residents of New Haven County, Connecticut were examined by area-based measures of race, ethnicity, and poverty. Area-based measures are aggregate descriptors of census tract characteristics useful for measuring differences in health outcomes in the context of where people live.
Cloned type III secretion systems have much potential to be used for bacterial engineering purposes involving protein secretion and substrate translocation directly into eukaryotic cells. We have previously cloned the SPI-1 and SPI-2 type III systems from the Salmonella enterica serovar Typhimurium genome using plasmid R995 which can conveniently capture large genomic segments for transfer between bacterial strains. However, though expressed and functional in Salmonella strains, cloned SPI-1 was previously observed to have a serious expression defect in other Gram negative bacteria including Escherichia coli.
View Article and Find Full Text PDFArticle Synopsis
- - The ydcI gene is a highly conserved transcriptional regulator found in various Gram-negative bacteria, significantly affecting phenotypes in Salmonella enterica serovar Typhimurium, but has not been studied extensively in other genera.
- - Different Gram-negative bacteria show varying tolerances to YdcI expression, with some non-tolerant genera experiencing a rapid loss of cell viability when YdcI levels increase, suggesting species-specific evolutionary adaptations.
- - YdcI expression not only leads to decreased viability but also increases sensitivity to multiple antibiotics, indicating its potential use in enhancing antibacterial treatments, and reveals important differences in regulatory mechanisms across bacterial species that need to be considered in future research.