Factors Associated With First-Time NCLEX-RN Success at a Predominantly Black Institution.

Background: Students from underrepresented groups, including those attending predominantly Black institutions, encounter challenges that hinder first-time success on the National Council Licensure Examination for Registered Nurses (NCLEX-RN).

Method: This retrospective, descriptive study included a convenience sample ( = 122) of nursing students. Data for students who attempted the NCLEX-RN at three different time periods were used to identify factors associated with passing the NCLEX-RN on the first attempt.

Impact of presymptomatic genetic testing for familial amyotrophic lateral sclerosis.

Purpose: The Pre-familial Amyotrophic Lateral Sclerosis (Pre-fALS) study is a longitudinal study of individuals potentially at risk for developing familial amyotrophic lateral sclerosis. Our goals were to (1) explore participants' decisions of whether to learn results of presymptomatic testing or not; (2) understand the psychosocial impact of these decisions; and (3) assess preferences for receiving results by telephone or in person.

Methods: The sample for this substudy comprised 20 participants drawn randomly from autosomal dominant mutant superoxide dismutase 1 families in the Pre-fALS study.

Exome sequencing reveals VCP mutations as a cause of familial ALS.

Using exome sequencing, we identified a p.R191Q amino acid change in the valosin-containing protein (VCP) gene in an Italian family with autosomal dominantly inherited amyotrophic lateral sclerosis (ALS). Mutations in VCP have previously been identified in families with Inclusion Body Myopathy, Paget disease, and Frontotemporal Dementia (IBMPFD).