The effects of psychotherapy, nefazodone, and their combination on subjective assessment of disturbed sleep in chronic depression.

Study Objectives: The purpose of the study was to compare the effects of psychotherapy, nefazodone, and their combination on subjective measures of sleep in patients with chronic forms of major depression.

Design: Participants were randomized to receive 12 weeks of treatment with one of the three interventions.

Setting: The study was conducted in parallel at 12 academic institutions and was approved by the Human Subjects Committee at each site.