Canonical correlation analysis of synchronous neural interactions and cognitive deficits in Alzheimer's dementia.

In previous work (Georgopoulos et al 2007 J. Neural Eng. 4 349-55) we reported on the use of magnetoencephalographic (MEG) synchronous neural interactions (SNI) as a functional biomarker in Alzheimer's dementia (AD) diagnosis.

Finding dementia in primary care: the results of a clinical demonstration project.

Objectives: To assess the effect of screening on diagnosing cognitive impairment.

Design: Quality improvement initiative.

Setting: Seven Veterans Affairs Medical Centers.

Screening for cognitive impairment in an elderly veteran population: acceptability and results using different versions of the Mini-Cog.

Objectives: To assess the feasibility of cognitive screening in older veterans presenting for routine primary care.

Design: Quality improvement initiative.

Setting: Seven Veterans Affairs Medical Centers.

Synchronous neural interactions assessed by magnetoencephalography: a functional biomarker for brain disorders.

We report on a test to assess the dynamic brain function at high temporal resolution using magnetoencephalography (MEG). The essence of the test is the measurement of the dynamic synchronous neural interactions, an essential aspect of the brain function. MEG signals were recorded from 248 axial gradiometers while 142 human subjects fixated a spot of light for 45-60 s.