Publications by authors named "Susan E Long"
Article Synopsis
- * Researchers analyzed 562 patients across four IEI subgroups (combined immunodeficiency, severe combined immunodeficiency, neutrophil disorders, and hemophagocytic lymphohistiocytosis-related disorders), focusing on event-free survival (EFS) as the main outcome.
- * The study concluded that targeting a cumulative busulfan exposure (AUCNONMEM) of around 80 mg × h/L can improve EFS and donor chimer
Busulfan is a commonly used alkylating agent in the conditioning regimens of hematopoietic cell transplantation (HCT). Population pharmacokinetic (popPK) models enable description of busulfan PK and optimization of exposure, which leads to improvement of event-free survival after HCT. Prior busulfan popPK analysis has been limited by small numbers in patients with inherited metabolic disorders (IMD).
View Article and Find Full Text PDFThe present study describes an analysis of genotype and allele distribution at the porcine GH locus among day-10 pig embryos. Embryos were collected post mortem from 6 crossbred (Danish Landrace x Yorkshire) sows inseminated with mixed Duroc semen and individually frozen for later analysis. After extraction, DNA was subjected to PCR amplification and restriction analysis with Msp I and Hae II enzymes.
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