Prospective cohort study assessing outcomes of patients from families fulfilling criteria for hereditary diffuse gastric cancer undergoing endoscopic surveillance.

Background: Prophylactic total gastrectomy is performed in hereditary diffuse gastric cancer (HDGC) patients carrying the CDH1 mutation because endoscopic surveillance often fails to detect microscopic disease.

Objective: The aim of this study was to determine the natural history and outcomes of patients with HDGC undergoing endoscopy.

Design: Prospective, cohort observational study.