Dose-Dependent Regulation on Prefrontal Neuronal Working Memory by Dopamine D Agonists: Evidence of Receptor Functional Selectivity-Related Mechanisms.

Low doses of dopamine D agonists improve working memory-related behavior, but high doses eliminate the improvement, thus yielding an 'inverted-U' dose-response curve. This dose-dependency also occurs at the single neuron level in the prefrontal cortex where the cellular basis of working memory is represented. Because signaling mechanisms are unclear, we examined this process at the neuron population level.