Publications by authors named "Susa Savukoski"
Acute injuries trigger an intense activation of the body's defense mechanisms aiming to limit damage and initiate healing. Among the crucial components of the intravascular immune system, the complement system plays a significant role in traumatic injuries, albeit often negatively. It has been suggested that excessive activation of the complement system, transitioning from a localized and timed response to a systemic one, can lead to a loss of its host-protective characteristics.
View Article and Find Full Text PDFSoluble terminal complement complex blood levels are elevated in schizophrenia.
Eur Arch Psychiatry Clin Neurosci
August 2024
Article Synopsis
- - The study investigated the complement system's role in unmedicated schizophrenia patients by measuring complement activation products before and after treatment, comparing results to matched controls.
- - While no significant differences in C5a, C4, or classical pathway function were found between patients and controls, plasma levels of the terminal complement complex (sTCC) were significantly higher in patients, indicating potential chronic immune activation.
- - The elevated sTCC levels were associated with C-reactive protein, suggesting sTCC could serve as a trait marker for immune response in schizophrenia; further research is recommended to track immune changes over time in early psychosis cases.
The complement system plays a crucial role in host defense, homeostasis, and tissue regeneration and bridges the innate and the adaptive immune systems. Although the genetic variants in complement C2 (c.839_849+17del; p.
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