Publications by authors named "Suryanarayana Allu"
Article Synopsis
- * The technique effectively produces spherical composite particles that dissolve better in water compared to traditional crystalline drugs, offering potential improvements in how medications work in the body.
- * Despite some challenges like needing a continuous water supply and managing solvent solubility, this method stands out for its flexibility and ability to create uniform particles, marking a significant step forward in drug formulation and delivery.
Cocrystallization of the drug-drug salt-cocrystal of the histone deacetylase inhibitor (HDACi) panobinostat (PAN) and b-rapidly accelerated fibrosarcoma (BRAF) inhibitor dabrafenib (DBF) afforded single crystals of a two-drug salt stabilized by N-H···O and N-H···N hydrogen bonds between the ionized panobinostat ammonium donor and dabrafenib sulfonamide anion acceptor in a 12-member ring motif. A faster dissolution rate for both drugs was achieved through the salt combination compared to the individual drugs in an aqueous acidic medium. The dissolution rate exhibited a peak concentration () of approximately 310 mg cm min for PAN and 240 mg cm min for DBF at a of less than 20 min under gastric pH 1.
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