Incidence and Progression of Diabetic Retinopathy in Urban India: Sankara Nethralaya Diabetic Retinopathy Epidemiology and Molecular Genetics Study, 15yr Follow up.

To evaluate the 15 year incidence and progression of Diabetic Retinopathy (DR) and identify risk factors among Indian population. From a cross-sectional study of 1425 subjects, 911 participants took part in the 4-year follow-up. Out of these 911 participants, 140 returned for the 15-year follow-up, with baseline examinations conducted between 2003 and 2006, and subsequent follow-ups occurring from 2007 to 2011 and the current 15-year follow-up from 2018 to 2021.

Can salivary and skin microbiome become a biodetector for aging-associated diseases? Current insights and future perspectives.

Growth and aging are fundamental elements of human development. Aging is defined by a decrease in physiological activities and higher illness vulnerability. Affected by lifestyle, environmental, and hereditary elements, aging results in disorders including cardiovascular, musculoskeletal, and neurological diseases, which accounted for 16.

Metabolomics insights of conventional and organic tempe during in vitro digestion and their antioxidant properties and cytotoxicity in HCT-116 cells.

Tempe, a fermented soybean food rich in polyphenols including isoflavones, is valued for its health benefits, notably its antioxidants. Concerns about glyphosate residues in crops have led to increased demand for organic soy products, including tempe. The study aimed to investigate the metabolomic profiles of tempe and its bioactive potentials prior to and following in vitro simulated gastrointestinal digestion.

Construction of CuYO/g-CN Novel Composite for the Sensitive and Selective Trace-Level Electrochemical Detection of Sulfamethazine in Food and Water Samples.

The most frequently used sulfonamide is sulfamethazine (SMZ) because it is often found in foods made from livestock, which is hazardous for individuals. Here, we have developed an easy, quick, selective, and sensitive analytical technique to efficiently detect SMZ. Recently, transition metal oxides have attracted many researchers for their excellent performance as a promising sensor for SMZ analysis because of their superior redox activity, electrocatalytic activity, electroactive sites, and electron transfer properties.

Fabrication of a Customized Ocular Prosthesis: A Case Report.

Orbital defects due to congenital causes, cancer, and trauma can compromise appearance and function, creating a deep psychological impact on an individual's life. The prosthetic rehabilitation of such patients is challenging. The objective of prosthetic treatment of an ocular defect is to provide a well-fitting ocular prosthesis that closely resembles the original eye, restoring the patient's self-confidence and social acceptance.

Modulation of Apoptotic, Cell Cycle, DNA Repair, and Senescence Pathways by Marine Algae Peptides in Cancer Therapy.

Marine algae, encompassing both macroalgae and microalgae, have emerged as a promising and prolific source of bioactive compounds with potent anticancer properties. Despite their significant therapeutic potential, the clinical application of these peptides is hindered by challenges such as poor bioavailability and susceptibility to enzymatic degradation. To overcome these limitations, innovative delivery systems, particularly nanocarriers, have been explored.

Evaluation of the Surface Roughness and Color Stability of Two Types of Milled Zirconia Before and After Immersion in Alcoholic Beverages: An In Vitro Study.

Objective This study aims to evaluate the effects of immersion in alcoholic beverages on the surface roughness and color stability of two types of milled zirconia. Materials and methods The sample size included 60 cuboid-shaped samples of two types of zirconia (Z1 and Z2), 30 in each group. Zirconia was milled and sintered at 1,500°C for eight hours.

Revealing the mechanism and efficacy of natural products on treating the asthma: Current insights from traditional medicine to modern drug discovery.

Asthma remains a significant global health challenge, demanding innovative approaches to treatment. Traditional medicine has a rich history of using natural products to alleviate asthmatic symptoms. However, transitioning from these traditional remedies to modern drug discovery approaches has provided fresh insights into the mechanisms and effectiveness of these natural products.

Diagnostic Utility of Swept-Source OCT-Based Biometry and Fundus Photographs Compared to Spectral Domain OCT in Center-Involving Diabetic Macular Edema.

Purpose: This study was aimed to evaluate the agreement between the swept-source optical coherence tomography (SS-OCT)-based biometry, fundus photographs, and their combination, in comparison to the gold standard spectral-domain optical coherence tomography (SD-OCT) for the detection of center-involving diabetic macular edema (CI-DME).

Methods: We conducted a retrospective cross-sectional study involving 55 subjects (78 eyes) diagnosed with diabetic macular edema (DME) detected clinically and on SD-OCT (Carl Zeiss Meditec AG). Post-mydriatic 45-degree color fundus photograph (Crystal-Vue NFC-700), 1 mm macular scan obtained from SS-OCT-based biometry (IOL-Master 700), and macula cube scan obtained from SD-OCT was used to detect and grade DME into CI-DME and NCI-DME.

Comparative Evaluation of Analgesic Efficacy of Ultrasound-Guided Pericapsular Nerve Group Block and Femoral Nerve Block During Positioning of Patients With Hip Fractures for Spinal Anesthesia: A Prospective, Double-Blind, Randomized Controlled Study.

Introduction: Hip fractures cause severe pain during positioning for spinal anesthesia (SA). Intravenous systemic analgesics can lead to various complications in elderly patients, hence peripheral nerve blocks are emerging as a standard of care in pain management for hip fractures, among which femoral nerve block (FNB) is widely known and practiced. Pericapsular nerve group (PENG) block is a recently described technique that blocks the articular nerves of the hip with motor-sparing effects and is used to manage positional pain in hip fractures.

Unraveling Light-Activated Insulin Action in Regulating Blood Glucose: New Photoactivatable Insight as a Novel Modality in Diabetes Management.

Diabetes, particularly type 2 diabetes (T2D), is the main component of metabolic syndrome. It is highly prevalent and has drastically increased with sedentary lifestyles, notably behaviors linked to ease of access and minimal physical activity. Central to this condition is insulin, which plays a pivotal role in regulating glucose levels in the body by aiding glucose uptake and storage in cells, and what happens to diabetes? In diabetes, there is a disruption and malfunction in insulin regulation.

Revealing Novel Source of Breast Cancer Inhibitors from Seagrass : In Silico and In Vitro Studies.

is a highly beneficial type of seagrass. Prior studies have presented proof of the bioactivity of , suggesting its potential to combat cancer. Therefore, this study aims to delve deeper into bioactive molecule profiles and their direct biological anticancer activities potentials through the combination of in-silico and in-vitro studies.

Association of eGFR with stages of diabetic retinopathy and age-related macular degeneration in Indian population.

Purpose: To investigate the influence of glomerular filtration rate in renal disease decline and its association with diabetic retinopathy (DR) and age-related macular degeneration (ARMD) in patients in South India.

Methods: A population-based cross-sectional study was conducted including participants with DR and ARMD recruited from urban and rural populations. The data collection included medical history, anthropometric measurements, and ophthalmic work-up.

Revealing Edible Bird Nest as Novel Functional Foods in Combating Metabolic Syndrome: Comprehensive In Silico, In Vitro, and In Vivo Studies.

Metabolic dysfunction, which includes intra-abdominal adiposity, glucose intolerance, insulin resistance, dyslipidemia, and hypertension, manifests into metabolic syndrome and related diseases. Therefore, the discovery of new therapies in the fight against metabolic syndrome is very challenging. This study aims to reveal the existence of an edible bird nest (EBN) as a functional food candidate that may be a new alternative in fighting metabolic syndrome.

The phenotypic diversity in the production performance of Alabio ducks ( Borneo) in South Kalimantan, Indonesia.

Objective: This study aimed to examine the diversity of phenotypic characteristics of female Alabio ducks ( Borneo) and their eggs in South Kalimantan, Indonesia.

Materials And Methods: A total of 200 18-month-old ducks and 300 eggs were selected using a survey method with multistage random sampling. These samples were obtained from two districts in the province of South Kalimantan [Banjar (BJ) districts and Tanah Laut (TL)].

New Insight on Biological Activities of Sulfated Polysaccharides from Ulvophyte Green Algae.

Green algae are natural bioresources that have excellent bioactive potential, partly due to sulfated polysaccharides (SPs) which are still rarely explored for their biological activities. There is currently an urgent need for studies exploring the anticancer biological activity of SPs extracted from two Indonesian ulvophyte green algae: the sulfated polysaccharide of (SPCr) and the sulfated polysaccharide of (SPCl). The method of isolating SPs and their assessment of biological activities in this study were based on previous and similar studies.

Green synthesis of novel YMnO-doped TiO for enhanced visible-light- driven photocatalytic degradation of malachite green.

Recently, new methods of utilizing chemistry materials to overcome environmental issues worldwide, for instance, water purification have widely evolved since it is well-aligned with the sustainable development goals 6: clean water and sanitation. These issues have become a vital research topic for researchers in the last decade, particularly, the use of green photocatalyst due to the limitation of renewable resources. Herein, we report the modification of titanium dioxide with yttrium manganite (TiO/YMnO) by a novel high-speed stirring technique in n-hexane-water utilizing Annona muricata L.

Deep learning-based detection of diabetic macular edema using optical coherence tomography and fundus images: A meta-analysis.

Diabetic macular edema (DME) is an important cause of visual impairment in the working-age group. Deep learning methods have been developed to detect DME from two-dimensional retinal images and also from optical coherence tomography (OCT) images. The performances of these algorithms vary and often create doubt regarding their clinical utility.

Application of xanthan gum as coagulant-aid for decolorization of synthetic Congo red wastewater.

In recent years, utilization of polysaccharides as natural coagulant and coagulant-aid has become a topic of interest, due to the nature of biopolymers that are renewable, biodegradable, and non-toxic. In this study, Congo red, as a model dye substance, was treated using polyaluminium chloride (PAC) as the main coagulant and xanthan gum as the coagulant aid. For this purpose, the effect of pH (3-9), xanthan gum dose (0.

Carotenoids Composition of Green Algae and Their Antidiabetic, Anti-Obesity, Antioxidant, and Anti-Inflammatory Properties.

Green alga is an underexploited species of macroalgae, even though it is characterized by a green color that indicates an abundance of bioactive pigments, such as chlorophyll and possibly xanthophyll. Unlike chlorophyll, which has been well explored, the composition of the carotenoids of and its biological activities have not been reported. Therefore, this study aims to look at the carotenoid profile and composition of and determine their biological activities, which include antidiabetic, anti-obesity, anti-oxidative, anti-inflammatory, and cytotoxicity in vitro.

Diagnostic capabilities of transperineal ultrasound (TPUS) to evaluate anal sphincter defect post obstetric anal sphincter injury (OASIS)? A systematic review.

Introduction: Endoanal ultrasound (3D-EAUS) is the gold standard imaging investigation for evaluating the anal sphincter; unfortunately, it is not universally available in most obstetric units. This study aims to appraise the ability of transperineal ultrasound (TPUS) compared with 3D-EAUS as the gold standard to identify anal sphincter defects after primary repair of OASIS.

Methods: A systematic search of major databases to identify diagnostic accuracy of 3D-TPUS in evaluating anal sphincter defects.

Defending against adversarial attacks on Covid-19 classifier: A denoiser-based approach.

Covid-19 has posed a serious threat to the existence of the human race. Early detection of the virus is vital to effectively containing the virus and treating the patients. Profound testing methods such as the Real-time reverse transcription-polymerase chain reaction (RT-PCR) test and the Rapid Antigen Test (RAT) are being used for detection, but they have their limitations.

Determining laboratory parameters in pregnant women with severe COVID-19.

Objective: Coronavirus disease causes a wide spectrum of clinical picture in pregnant women. There are still a few studies concerning laboratory parameters to differentiate the severity of coronavirus disease-19 in pregnant patients. This article aims to identify the cut-off on laboratory parameters between pregnant women with asymptomatic/mild/moderate and severe/critical coronavirus disease-19 illness.