Publications by authors named "Surya Prakash Rao Pydimarry"
Quality by design tool-evaluated stability-indicating ultra-performance liquid chromatography method for the determination of drugs (ritonavir and darunavir) used to treat the human immunodeficiency virus/acquired immunodeficiency syndrome.
Biomed Chromatogr
September 2023
Ritonavir and darunavir were examined using a ultra-performance liquid chromatography (UPLC) approach in pharmaceutical dosage forms. The small number of analytical studies that are currently available do not demonstrate the method's stability or nature. The study sought to assess both chemicals using a stability-indicating approach with a relatively short run time.
View Article and Find Full Text PDFRegulatory Perspective Reverse Engineering Analysis of the Mast Cell Stabilizer and the Histamine Receptor Antagonist (Olopatadine HCl): Instrumental and Classical Methods for Multiple Formulations.
ACS Omega
June 2023
Article Synopsis
- - The study focuses on evaluating the qualitative and quantitative aspects of olopatadine HCl nasal spray and ophthalmic solutions by using various techniques to match generic formulations with reference drugs, avoiding the need for clinical trials.
- - A highly sensitive HPLC method was utilized to accurately quantify ingredients such as EDTA, BKC, NaCl, and DSP in both formulations, demonstrating that they have similar components.
- - The methods used for analysis showed high accuracy and precision, with correlation coefficients over 0.999 and recovery rates ranging from 99.1% to 100.8%, confirming their reliability in identifying the components in the formulations.
The current aim of this study is to develop a simple, sensitive, and robust analytical method that can separate the Rivaroxaban and its related impurities by using HPLC. This new method can separate enantiomers and all the process-related impurities of rivaroxaban. This method can also be used to determine the assay of rivaroxaban in drug substances and drug products.
View Article and Find Full Text PDFA simple, sensitive and reproducible method was developed on ultra-performance liquid chromatography coupled with photodiode array detection for the quantitative determination of dronedarone hydrochloride (DRO) in drug substance and pharmaceutical dosage forms. The method is applicable for the quantification of related substances and assays of drug substances. Chromatographic separation was achieved on Acquity UPLC BEH C8 100 mm, 2.
View Article and Find Full Text PDFA simple, sensitive, precise and accurate stability-indicating ultra-performance liquid chromatography (UPLC) method was developed for the quantitative determination of the purity of the active pharmaceutical ingredient of milnacipran hydrochloride (MCP) and its pharmaceutical dosage form in the presence of its process-related impurities and degradation products. The proposed UPLC method utilizes Acquity UPLC BEH 100 mm, 2.1 mm and 1.
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