Investigation of alpha-glucosidase inhibition activity of Artabotrys sumatranus leaf extract using metabolomics, machine learning and molecular docking analysis.

One way to treat diabetes mellitus type II is by using α-glucosidase inhibitor, that will slow down the postprandial glucose intake. Metabolomics analysis of Artabotrys sumatranus leaf extract was used in this research to predict the active compounds as α-glucosidase inhibitors from this extract. Both multivariate statistical analysis and machine learning approaches were used to improve the confidence of the predictions.

Optimization of machining parameters while turning AISI316 stainless steel using response surface methodology.

The chromium-nickel alloy known as AISI 316 Stainless Steel is extensively used in various industries, such as the chemical industry, nuclear power plants, and medical devices, due to its exceptional mechanical properties and corrosion resistance. Compared to other stainless steels, AISI 316 resists corrosion from air and other corrosive conditions better. Determining the optimal selection of machining parameters is still a challenge for many researchers.

Prediction of android ransomware with deep learning model using hybrid cryptography.

In recent times, the number of malware on Android mobile phones has been growing, and a new kind of malware is Android ransomware. This research aims to address the emerging concerns about Android ransomware in the mobile sector. Previous studies highlight that the number of new Android ransomware is increasing annually, which poses a huge threat to the privacy of mobile phone users for sensitive data.

Green synthesis of cerium oxide nanoparticles using: characterization and evaluation of antioxidant, anti-inflammatory and antibacterial efficacy against wound isolates.

Multi-drug resistance (MDR) infections are a significant global challenge, necessitating innovative and eco-friendly approaches for developing effective antimicrobial agents. This study focuses on the synthesis, characterization, and evaluation of cerium oxide nanoparticles (CeONPs) for their antioxidant, anti-inflammatory, and antibacterial properties. The CeONPs were synthesized using aaqueous extract through an environmentally friendly process.

Sarcopenia in cirrhosis: Unraveling the prevalence and relationships with liver disease severity and complications.

Background And Objectives: Sarcopenia in cirrhosis is associated with poor survival and adverse pre and post-transplant outcomes. The study aimed at determining the prevalence of sarcopenia and its association with the severity, complications and etiology of liver disease.

Methods: As many as 416 cirrhotic patients who met the inclusion criteria underwent muscle strength testing using a dynamometer.

Green Synthesis of Molybdenum Nanoparticles From Solanum xanthocarpum and Evaluation of Their Antimicrobial and Antioxidant Activity Against Multidrug-Resistant Wound Isolates.

Introduction: In recent years, antimicrobial drug resistance has emerged as a serious global public health concern, according to the World Health Organization data. The emergence of pathogens resistant to multiple drugs has been linked to an increase in morbidity and mortality from microbial infections. The study's main goal is to explore the efficacy of using in the green synthesis of molybdenum nanoparticles (Mo NPs) for antibacterial and antioxidant properties.

Green Synthesis of Aluminum Oxide Nanoparticles Using Clerodendrum phlomidis and Their Antibacterial, Anti-inflammatory, and Antioxidant Activities.

Introduction:  plays a significant role in many indigenous medical systems, and it can be mostly found in Southeast Asia. The objective of the study was to synthesize and characterize the biosynthesized aluminum oxide nanoparticles (AlO-NPs) using and analyze their antibacterial (bactericidal), antioxidant, and anti-inflammatory activities.

Methods: The extract was prepared by the autoclave-assisted method, and the AlO-NPs were synthesized by the green synthesis method.

Evaluation of Antibacterial, Antioxidant, Anti-inflammatory and Anticancer Efficacy of Titanium-Doped Graphene Oxide Nanoparticles.

Introduction: The current development of nanoparticles (NPs) with significant antibacterial properties, low cost and low toxicity has made it possible to develop novel techniques for treatments in the medical field. The titanium metal oxide, when combined with a carbonaceous material like graphene, which has excellent absorbing capacity, is efficient in loading drugs and thus helps in drug delivery and also in biomedical applications like anticancer, anti-inflammatory, antioxidant, and antibacterial activities.

Materials And Methods: Titanium-doped graphene oxide nanoparticles (Ti/GO-NPs) were processed by the one-pot synthesis method; further characterization was performed by using UV-visible spectroscopy, Fourier transform-infrared spectroscopy (FT-IR), field emission electron microscopy (FE-SEM), and energy-dispersive X-ray spectroscopy (EDX) analysis and biomedical applications like anticancer, anti-inflammatory, antioxidant and antibacterial activities.

A Novel cause of Massive Hepatosplenomegaly with Fibrosis in two children: Transient Infantile Hypertriglyceridemia.

Background: Transient infantile hypertriglyceridemia (TIH) is a syndrome of hypertriglyceridemia, fatty liver, and deranged liver functions with progression to fibrosis and cirrhosis. It is an autosomal recessive disorder caused by mutations in Glycerol-3-phosphate dehydrogenase 1 gene present on Chromosome 12q12-q13, and has been reported in Israeli Arab families with high consanguinity. TIH is suspected by high serum triglyceride levels and steatosis on liver biopsy; however, diagnosis is confirmed on clinical exome sequencing

Clinical Description: We present two cases of TIH belonging to the indigenous Hindu, hilly population of Himachal Pradesh in North India with no history of either consanguinity or family history.

Pathogenesis Analysis of Salivary Gland Tumors Through the Expression of Programmed Death-Ligand 1 (PD-L1).

Pleomorphic adenoma (PA) is the most common salivary gland neoplasm, followed by Warthin's tumor (WT). In addition to its high frequency, PA also shows metastasis and transformation towards malignancy as carcinoma ex-pleomorphic adenoma (CXPA). While the histogenesis of WT remains unclear, especially given the presence of lymphoid stroma around the developing tumor and the immunological interaction between them.

Clinician's dilemma: Naproxen-induced liver injury.

Naproxen is a widely used nonsteroidal anti-inflammatory drug (NSAID) in pediatric population, used for mild-to-moderate pains, arthritis, and other immune-mediated disorders. It rarely causes clinically apparent liver injury in the adult population taking high doses of the drug over a prolonged period and is reported even rarer in pediatric population. We present a case of drug-induced liver injury (DILI) in a 13-year-old girl taking naproxen in therapeutic doses for juvenile rheumatoid arthritis.

Black gram Plant Leaf Disease (BPLD) dataset for recognition and classification of diseases using computer-vision algorithms.

This article introduces Black gram Plant Leaf Disease (BPLD) dataset, which is scientifically called as and is popularly known as Urad in India. It is widely considered to be one of the most significant pulse crops farmed in India. Anthracnose, Leaf Crinkle, Powdery Mildew and Yellow Mosaic diseases shown significant impact on the black gram production and causing financial loss to the farmers.

Utility of Urinary Nephrin in Patients With and Without Diabetic Nephropathy and Its Correlation With Albuminuria.

Introduction Nephrin is a podocyte-specific protein that may serve as a urinary biomarker in patients with diabetic nephropathy. The objectives of the study were to determine urinary nephrin levels in patients with and without type 2 diabetic nephropathy and to assess the correlation between urinary nephrin and albuminuria. Methods This was a cross-sectional comparative study that was carried out at Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry over 18 months.

Signs and lines in lung ultrasound.

Point-of-care ultrasound has become firmly established in acute and critical care settings, and is now increasingly being used as an important tool in the assessment of the lungs. In this article, we briefly describe the technique of lung ultrasound and the various lines and signs commonly encountered during sonography of the lung, namely the normally visualised A- and T-lines and the bat sign, sliding sign (power slide sign on colour Doppler), sea-shore sign, curtain sign, and the lung pulse. We have also described signs seen in various pathological conditions like B-lines seen in cases of increased lung density; the quad sign, sinusoid sign, thoracic spine sign, plankton sign and the jelly fish sign seen in pleural effusion; the stratosphere sign and the lung point sign seen in pneumothorax; the shred/fractal sign and tissue-like sign in consolidation, and the double lung point sign seen in transient tachypnoea of the newborn.

Characterization of from spontaneous melioidosis in a Bornean orangutan.

Background And Aim: Melioidosis is a potentially fatal disease affecting humans and a wide range of animal species; it is often underdiagnosed and underreported in veterinary medicine in Indonesia. This study aimed to characterize morphological and molecular features of , the causative agent of melioidosis which caused the death of a Bornean orangutan.

Materials And Methods: Pulmonary abscess samples were cultured on several types of media, including Ashdown agar, Ashdown broth, and MacConkey agar.

"Crown of Death"; Corona Mortis, a Common Vascular Variant in Pelvis: Identification at Routine 64-Slice CT-Angiography.

Objective: To establish the incidence of arterial corona mortis variant in angiographic studies being performed using a 64 slice CT scan machine in a series of patients.

Methods: This was a prospective cross-sectional study including 100 consecutive patients undergoing routine clinically indicated, standard protocol, CT-angiography for the abdominal aorta and/or lower limbs using a 64 slice CT scanner. Patients having severe arterial insufficiency (Grade 4 stenosis on CT angiography), pelvic infections and tumours, patients with past pelvic trauma and those who had previous pelvic surgery were excluded from the study.

Classic Imaging Features of L-2-Hydroxyglutaric Aciduria in Young Adult Presenting as Seizures Associated with Fever.

L-2 Hydroxyglutaric aciduria is a rare metabolic disorder which is autosomal recessive in inheritance. It is characterised by the increased urinary excretion of L-2 hydroxyglutaric acid and the diagnosis is based on the increased levels of the L-2 hydroxy glutaric acid in the urine, serum & CSF. This is a neurometabolic disorder which is associated with slowly progressive psychomotor delay since childhood.

Study of ultrasound-guided needle aspiration and catheter drainage in the management of liver abscesses.

Purpose: To evaluate and compare the efficacy of intermittent needle aspiration and continuous catheter drainage in ultrasound-guided management of liver abscesses.

Methods: This was a prospective, randomised study conducted on 100 patients (88 males and 12 females; age range 22-74 years) with liver abscess(es) and having abscess size more than 5 cm, divided into two groups: Percutaneous needle aspiration (PNA) (n = 50) and percutaneous catheter drainage (PCD) (n = 50). Criteria of exclusion were: rupture of abscess before intervention; prior intervention; uncorrectable coagulopathy; concomitant biliary tract malignancy.

To Compare Diagnostic Ability of Contrast-Enhanced Three-Dimensional T1-SPACE with Three-Dimensional Fluid-Attenuated Inversion Recovery and Three-Dimensional T1-Magnetization Prepared Rapid Gradient Echo Magnetic Resonance Sequences in Patients of Meningitis.

Aims: The aim of this study is to compare postcontrast three-dimensional (3D) T1-Sampling perfection with application-optimized contrasts by using different flip angle evolutions, 3D fluid-attenuated inversion recovery (FLAIR), and 3D T1-magnetization prepared rapid gradient echo (MPRAGE) sequences in patients of meningitis.

Settings And Design: A hospital-based cross-sectional study done in the Department of Radiodiagnosis, IGMC Shimla for a period of 1 year from June 1, 2016, to May 30, 2017.

Subjects And Methods: A total of 30 patients suspected of meningitis underwent magnetic resonance imaging evaluation with postcontrast 3D T1-MPRAGE, 3D T1-SPACE, and 3D FLAIR sequences.

The Importance of Mental Well-Being for Health Professionals During Complex Emergencies: It Is Time We Take It Seriously.

We call on humanitarian aid organizations to integrate proven mental health strategies to protect the mental health of their workforce and improve staff capacity to provide care for vulnerable populations. Such strategies could include: Pre-deployment training. Art therapy.

Isolated Fracture of Lateral Pterygoid Plate by Penetrating Foreign Body - A Rarity Indeed.

Background: Fractures of mid-face were first described by Le Fort and are classified into three categories - Le Fort I, Le Fort II and Le Fort III. The pterygoid processes of the sphenoid bone are fractured in all the three categories of Le Fort fractures as the sphenoid bone connects the cranium vault to the facial bones. Fractures of the pterygoid processes without associated Le Fort fractures are rare and are usually associated with fractures of the mandible, temporal bone or other facial bones.