Paraoxonase 3: Structure and Its Role in Pathophysiology of Coronary Artery Disease.

Spanning three decades in research, Paraoxonases (PON1) carried potential of dealing with neurotoxicity of organophosphates entering the circulation and preventing cholinergic crisis. In the past few years, the Paraoxonase multigene family () has been shown to play an important role in pathogenesis of cardiovascular disorders including coronary artery disease (CAD). The genes are clustered in tandem on the long arm of human chromosome 7 (q21, 22).

Long-term outcome in children with juvenile dermatomyositis: A single-center study from north India.

Introduction: Juvenile dermatomyositis (JDM) is the commonest childhood inflammatory myopathy. Outcome of children with JDM has improved significantly with current treatment protocols. We undertook this study to evaluate long-term outcome of these children using validated outcome measures.

Prevalence of multidrug resistance tuberculosis in adult patients in India: A systematic review and meta-analysis.

Background: Multidrug resistance tuberculosis (MDR-TB) is an important public health problem for India but there is a paucity of data related to the prevalence of MDR-TB in India. This systematic review and meta-analysis was designed to synthesize evidence regarding the prevalence of MDR-TB in adult patients in India.

Methods: PubMed and Google Scholar were searched to find different observational studies reporting MDR-TB prevalence in India.

Arsenic mitigation in rice grain loading via alternative irrigation by proposed water management practices.

Over the past three decades, the occurrence of high concentrations of arsenic (As) in drinking-water and its subsequent poisoning in rice has been recognized as a major public-health concern globally, especially in Ganga Delta Plain with more than 80 million peoples in serious As exposure far beyond than its allowable limit. An extensive field study was conducted for consecutive four years viz. 2013 to 2016, introducing a process of intermittent irrigation pattern comparing to the conventional practice of rice cultivation in India.

Flow Cytometry for Diagnosis of Primary Immune Deficiencies-A Tertiary Center Experience From North India.

Flow cytometry has emerged as a useful technology that has facilitated our understanding of the human immune system. Primary immune deficiency disorders (PIDDs) are a heterogeneous group of inherited disorders affecting the immune system. More than 350 genes causing various PIDDs have been identified.

Diagnostic accuracy of 3-T lung magnetic resonance imaging in human immunodeficiency virus-positive children.

Background: More than 70% of human immunodeficiency virus (HIV)-positive children sustain respiratory diseases in their lifetime. Imaging plays an important role in establishing early and correct diagnosis.

Objective: To evaluate the diagnostic accuracy of 3-Tesla (T) thorax MRI in HIV-positive children, using chest CT as the gold standard.

Neurological Manifestations Do not Affect Cumulative Survival in Indian Patients with Antineutrophil Cytoplasmic Antibody Associated Vasculitis.

Background: Neurological manifestations are an important cause of morbidity in antineutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV). It is not clear whether or not they are indicative of a severe disease course with multiple organ involvement and shortened survival.

Aims And Objectives: To characterize the neurological manifestations of AAV and analyze their relationship with other organ system and cumulative survival.

Esophageal manometry, esophagogastroduodenoscopy, and duodenal mucosal histopathology in systemic sclerosis.

Background And Aim: Systemic sclerosis (SSc) is known to involve the gastrointestinal (GI) tract, resulting in dysmotility, gastroesophageal reflux disease, and mucosal changes causing significant morbidity. The study aimed to assess esophageal motility and duodenal mucosal changes in SSc.

Methods: This is a prospective, cross-sectional, single-center study of 23 patients with SSc diagnosed on the basis of standard criteria.

Biomarkers for Kawasaki Disease: Clinical Utility and the Challenges Ahead.

Kawasaki disease (KD) has replaced acute rheumatic fever as the most common cause of acquired heart disease in children in the developed world and is increasingly being recognized from several developing countries. It is a systemic vasculitis with a predilection for coronary arteries. The diagnosis is based on a constellation of clinical findings that appear in a temporal sequence.

Rheumatology Panel in Pediatric Practice.

Common rheumatological disorders encountered in pediatric practice are juvenile idiopathic arthritis, systemic juvenile idiopathic arthritis, Kawasaki disease, Henoch-Schonlein purpura, systemic lupus erythematosus, chronic uveitis and juvenile dermatomyositis. Diagnosis of these disorders requires a critical appraisal of the clinical history, physical examination and relevant investigations. Laboratory tests are helpful for screening purposes as also for confirmation of diagnosis and monitoring of disease activity.

A young female with early onset arthritis, uveitis, hepatic, and renal granulomas: a clinical tryst with Blau syndrome over 20 years and case-based review.

Blau syndrome is a rare autosomal dominant monogenic auto-inflammatory disorder characterized by triad of granulomatous polyarthritis, dermatitis, and uveitis. However, it may be difficult to recognize this syndrome in the absence of all three characteristic clinical manifestations. A 3-year-old girl presented with early onset symmetric polyarthritis and developed granulomatous uveitis at 13 years of age.

X-linked agammaglobulinemia (XLA):Phenotype, diagnosis, and therapeutic challenges around the world.

Background: X-linked agammaglobulinemia is an inherited immunodeficiency recognized since 1952. In spite of seven decades of experience, there is still a limited understanding of regional differences in presentation and complications. This study was designed by the Primary Immunodeficiencies Committee of the World Allergy Organization to better understand regional needs, challenges and unique patient features.