Role of Doxorubicin on the Loading Efficiency of ICG within Silk Fibroin Nanoparticles.

The effective loading or encapsulation of multimodal theranostic agents within a nanocarrier system plays an important role in the clinical development of cancer therapy. In recent years, the silk fibroin protein-based delivery system has been drawing significant attention to be used in nanomedicines due to its biocompatible and biodegradable nature. In this study, silk fibroin nanoparticles (SNPs) have been synthesized by a novel and cost-effective ultrasonic atomizer-based technique for the first time.

Effect of Doxorubicin on the Near-Infrared Optical Properties of Indocyanine Green.

In recent years, chemo-photothermal therapy (chemo-PTT) has been extensively studied for the upgradation of cancer treatment. The combined therapeutic approach reduces the overall cytotoxicity and enhances the therapeutic effect against the cancerous cells. In chemo-PTT, Indocyanine green (ICG) dye, a near-infrared chromophore, is used for PTT in combination with doxorubicin (DOX), a chemotherapeutic drug.

Optical-Property-Enhancing Novel Near-Infrared Active Niosome Nanoformulation for Deep-Tissue Bioimaging.

Indocyanine green (ICG) is a clinically approved near-infrared (NIR) contrast agent used in medical diagnosis. However, ICG has not been used to its fullest for biomedical imaging applications due to its low fluorescence quantum yield, aqueous instability, concentration-dependent aggregation, and photo and thermal degradations, leading to quenching of its fluorescence emission. In the present study, a nanosized niosomal formulation, ICGNiosomes (ICGNios), is fabricated to encapsulate and protect ICG from degradation.

Fluorescence photobleaching of urine for improved signal to noise ratio of the Raman signal - An exploratory study.

Urine analysis is an important clinical test routinely performed in pathology labs for disease diagnosis and prognosis. In recent years, near-infrared Raman spectroscopy has drawn considerable attention for urine analysis as it can provide rapid, reliable, and reagent-free analysis of urine samples. However, one important practical problem encountered in such Raman measurements is the orders of magnitude stronger spectral background preventing one to utilize the full dynamic range of the detector which is required for the measurement of Raman signal with good signal-to-noise ratio (SNR).

Green synthesis of near-infrared absorbing eugenate capped iron oxide nanoparticles for photothermal application.

Nanomaterials exhibit different interesting physical, chemical, electronic and magnetic properties that can be used in a variety of biomedical applications such as molecular imaging, cancer therapy, biosensing, and targeted drug delivery. Among various types of nanoparticles, super paramagnetic iron oxide nanoparticles (SPIONs) have emerged as exogenous contrast agents for in vitro and in vivo deep tissue imaging. Here, we propose a facile, rapid, non-toxic, and cost-effective single step green synthesis method to fabricate eugenate (4-allyl-2-methoxyphenolate) capped iron oxide nanoparticles (E-capped IONPs).

Fluorescence photo-bleaching of urine and its applicability in oral cancer diagnosis.

Photo-stability of urine is of crucial importance for the applicability of fluorescence spectroscopy of urine samples for diagnosis of cancer. We report the results of a detailed study on fluorescence photo-bleaching of human urine samples. We also present the results of a preliminary investigation on evaluation of the applicability of photo-bleaching characteristics of urine for discriminating patients with oral cancer from healthy volunteers.

Nanotrap-Enhanced Raman Spectroscopy: An Efficient Technique for Trace Detection of Bioanalytes.

Reliable diagnosis of disease using body fluids requires sensitive and accurate detection of disease-specific analytes present in the fluid. In recent years, there has been increasing interest in using surface-enhanced Raman spectroscopy (SERS) for this purpose. The demonstrable signal enhancement and sensitivity of SERS makes it ideally suited for detection of a trace quantity of any analyte.