Restricted Cortical Activity Involving Parietal Lobe and Sublobar Region Leads to Generalized Spike-Wave Discharges of Juvenile Myoclonic Epilepsy: Evidence from an EEG Source Localization Study.

Background: Previous studies have localized the origin of "generalized" spike-wave discharges of idiopathic generalized epilepsies to specific brain regions. Although there are studies in juvenile myoclonic epilepsy (JME) which have investigated the origin of spike-wave discharges, reports on the propagation of discharges are sparse.

Objective: The current study investigated the propagation of spike-wave discharges in JME, which was investigated by statistically comparing the electroencephalography (EEG)-derived cortical source activity during (a) various phases of spike-wave discharge versus background (eyes closed) activity, and (b) various phases of the first spike wave versus the corresponding phase of subsequent spike waves.

Effect of short-term exposure to Raag Bilawal of North Indian classical music on young Indian adults: a high-density electroencephalogram microstate study.

Introduction: the objective of the study was to find out the microstate map topographies and their parameters generated during the resting state and during listening to North Indian classical Music Raag 'the Raag Bilawal'. It was hypothesized that in the resting state and during listening to music conditions, there would be a difference in microstate parameters i.e.

Global Effect on Cortical Activity in Young Indian Males in Response to "OM" Chanting: A High-Density Quantitative Electro-Encephalography Study.

Background: Meditation using the "OM" mantra is the most widely used practice in India. Though reports have been published about the relaxation effect during both verbal "OM" chanting and listening to "OM" chanting, there is a paucity of literature concerning the cortical areas activated/deactivated after verbal "OM" chanting and listening to "OM" chanting using quantitative electro-encephalography (qEEG).

Purpose: The objective of this study was to compare the effects of verbal "OM" chanting and listening to "OM" chanting on cortical sources as compared to baseline, as assessed by qEEG.

Multi-domain Cognitive Testing: A Biomarker for Classifying the Cognitive Status of Mild Cognitive Impairment and Alzheimer's Disease.

Context: Cognition is impaired in Alzheimer's disease (AD) and patients with mild cognitive impairment (MCI) with varying levels of magnitude.

Aim: The present study aimed to identify a biomarker for classifying MCI and AD using multi-domain cognitive testing.

Settings And Design: This was a cross-sectional study.

Does suprahyoid muscle complex pull cause relapse following genial advancement by distraction osteogenesis? An electromyographic study.

Active pull of the suprahyoid muscle complex (SMC) was thought to be the main contributor of relapse in mandibular or chin advancement, but literature evidence lacks human studies that assess the role of the SMC following genial advancement (GeA). This study therefore aimed to analyse the influence of SMC pull on relapse following GeA by distraction osteogenesis based on electromyographic (EMG) changes. EMG was recorded and analysed preoperatively (T0), at four months (T1), and at one-year follow up (T2) at three submental regions during two different activities.

An Integrated Dynamic Closed Loop Simulation Platform for Elbow Flexion Augmentation Using an Upper Limb Exosuit Model.

Wearable robotic devices are designed to assist, enhance or restore human muscle performance. Understanding how a wearable robotic device changes human biomechanics through complex interaction is important to guide its proper design, parametric optimization and functional success. The present work develops a human-machine-interaction simulation platform for closed loop dynamic analysis with feedback control and to study the effect of soft-robotic wearables on human physiology.

Altered spontaneous cortical activity in mild glaucoma: A quantitative EEG study.

Functional neuroimaging studies have reported alterations in cortical activity indicating glaucoma as a progressive neurodegenerative disease. Hence the current study aimed to assess the cortical activity using high-density EEG in patients with mild glaucoma during resting state. Treatment-naive 37 patients with primary open angle glaucoma (POAG), 34 patients with primary angle closure glaucoma (PACG), and 32 healthy controls were included in the study.

Reduced Resting-State Cortical Alpha Connectivity Reflects Distinct Functional Brain Dysconnectivity in Alzheimer's Disease and Mild Cognitive Impairment.

Emerging evidence suggests distinct abnormal activity patterns during resting state in intrinsic functional brain networks in patients with neurodegenerative diseases, including Alzheimer's disease (AD) and mild cognitive impairment (MCI). This study aimed to identify the changes in the resting-state intracortical lagged phase synchronization derived from dense array electroencephalography (EEG) in AD and MCI. Resting-state current source density (CSD) and lagged phase synchronization between 84 regions of interest defined by Brodmann areas (BAs) for seven EEG frequency bands were investigated between the study groups (AD, MCI, and age-matched controls) using 128-channel EEG.

IUPS Physiology Education Workshop series in India: organizational mechanics, outcomes, and lessons.

Active learning promotes the capacity of problem solving and decision making among learners. Teachers who apply instructional processes toward active participation of learners help their students develop higher order thinking skills. Due to the recent paradigm shift toward adopting competency-based curricula in the education of healthcare professionals in India, there is an emergent need for physiology instructors to be trained in active-learning methodologies and to acquire abilities to promote these curriculum changes.

Cingulate oscillatory activity reflects the quality of memory representations in visuospatial working memory.

The human brain has the high likelihood for committing errors when confronted by a day-to-day situation that demands to process more than four integrated items in working memory, for example driving a car to a new destination in high traffic. However, neural mechanisms underlying the response outcome in working memory is still unclear. High temporal resolution and improved spatial resolution of dense array electroencephalogram (EEG) make it an ideal tool to investigate the dynamics of brain networks.

Altered parahippocampal gyrus activation and its connectivity with resting-state network areas in schizophrenia: An EEG study.

Synchronized and coherent activity in resting-networks during normal brain functioning could be altered in disconnection syndrome like schizophrenia. Study of neural oscillations as assessed by EEG appears to be a promising proposition to understand the pathophysiology of schizophrenia in patients and their first-degree relatives, where disturbances in neural oscillations point towards genetic predisposition. Therefore, present study aims at establishing EEG based biomarkers for early detection and management strategies.

Microteaching enhances teaching skills of resident doctors in India: A pilot study.

Background: The Medical Council of India has recommended microteaching for training medical graduates to improve their teaching efficiency. We assessed the effectiveness of microteaching on teaching skills of resident doctors through objective and subjective methods.

Methods: We obtained data from three microteaching sessions in which 10 resident doctors participated.

Brain Networks Communicate Through Theta Oscillations to Encode High Load in a Visuospatial Working Memory Task: An EEG Connectivity Study.

The encoding of visuospatial information is the foremost and indispensable step which determines the outcome in a visuospatial working memory (VSWM) task. It is considered to play a crucial role in limiting our ability to attend and process only 3-5 integrated items of information. Despite its importance in determining VSWM performance, the neural mechanisms underlying VSWM encoding have not been clearly differentiated from those involved during VSWM retention, manipulation and/or retrieval.

Planning, implementation, and evaluation of multicomponent, case-based learning for first-year Indian medical undergraduates.

Didactic lecture is an effective method to quickly pass on a high volume of information to a large number of students. However, if not well designed, lectures can be monotonous and provide only passive learning, with little scope for higher order learning skills. To address this drawback of lectures, we supplemented it with case-based learning (CBL), which has been shown to promote self-learning.

Pre-trial and pre-response EEG microstates in schizophrenia: An endophenotypic marker.

Cognitive deficits in Schizophrenia interfere with everyday functioning and social functioning. Strong familial associations in schizophrenia might serve to establish cognitive impairments as endophenotypic markers. Therefore, visuo-spatial working memory simulating day-to-day activities at high memory load was assessed in patients with schizophrenia, their first-degree relatives and healthy controls to explore pre-trial and pre-response EEG microstates and their intracranial generators.

A novel method for assessing patients with schizophrenia and their first-degree relatives by increasing cognitive load of visuo-spatial working memory.

Introduction: In patients with schizophrenia, social and functional outcome is determined by the cognitive impairment. Assessment of visuo-spatial working memory (VSWM) which can simulate the day-to-day activities by simultaneous involvement of various elements of working memory may reflect disorganized thinking and fragmentation of thoughts in schizophrenia.

Methods: Thirty-six patients with schizophrenia, 29 first-degree relatives of patients, and 25 healthy controls performed a VSWM task with three memory loads (comprising three pairs, six pairs, and eight pairs of abstract pictures).

Hyperactivation of left inferior parietal lobule and left temporal gyri shortens resting EEG microstate in schizophrenia.

Objective: The momentary spatial configuration of the brain electric field at the scalp reflects quasi-stable "functional microstates" caused by activity of different intracranial generators. There is paucity in literature on the intracranial generators of resting state EEG microstate alterations in stable patients with schizophrenia. The present study aimed to investigate resting state microstate alterations and their neural generators in patients with schizophrenia and their first-degree relatives as compared to healthy controls in an attempt to establish state and trait marker.

Functional brain microstate predicts the outcome in a visuospatial working memory task.

Humans have limited capacity of processing just up to 4 integrated items of information in the working memory. Thus, it is inevitable to commit more errors when challenged with high memory loads. However, the neural mechanisms that determine the accuracy of response at high memory loads still remain unclear.